| Chen Weiwei,Wang Wenling,Wang Gang,Li Xiaokai,Li Guodong,Dong Hongmin.Correlation analysis of XRCC1 gene rs25487 polymorphism and effect of concurrent neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a prospective cohort study[J].Chinese Journal of Radiological Medicine and Protection,2020,40(10):740-745 |
| Correlation analysis of XRCC1 gene rs25487 polymorphism and effect of concurrent neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a prospective cohort study |
| Received:May 21, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.10.002 |
| KeyWords:Rectal cancer Neoadjuvant chemoradiotherapy X-ray cross-complementary gene 1 Gene polymorphism Interaction |
| FundProject:贵州省教育厅青年科技人才成长项目（黔教合KY字[2016]151） |
| Author Name | Affiliation | E-mail | | Chen Weiwei | Department of Abdominal Oncology, Affiliated Hospital of Guizhou Medical University, Guizhou Cancer Hospital, Guizhou Medical University, Guiyang 550000, China | | | Wang Wenling | Department of Abdominal Oncology, Affiliated Hospital of Guizhou Medical University, Guizhou Cancer Hospital, Guizhou Medical University, Guiyang 550000, China | 2276853380@qq.com | | Wang Gang | Department of Abdominal Oncology, Affiliated Hospital of Guizhou Medical University, Guizhou Cancer Hospital, Guizhou Medical University, Guiyang 550000, China | | | Li Xiaokai | Department of Abdominal Oncology, Affiliated Hospital of Guizhou Medical University, Guizhou Cancer Hospital, Guizhou Medical University, Guiyang 550000, China | | | Li Guodong | Department of Abdominal Oncology, Affiliated Hospital of Guizhou Medical University, Guizhou Cancer Hospital, Guizhou Medical University, Guiyang 550000, China | | | Dong Hongmin | Department of Abdominal Oncology, Affiliated Hospital of Guizhou Medical University, Guizhou Cancer Hospital, Guizhou Medical University, Guiyang 550000, China | |
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| Abstract:: |
| Objective To investigate the correlation between the X-ray cross-complementary gene 1 (XRCC1) rs25487 gene polymorphism and the effect of neoadjuvant chemoradiotherapy for locally advanced rectal cancer (LARC ). Methods This research was a prospective cohort study consisting of 55 patients with LARC who were treated in the Affiliated Hospital, Guizhou Cancer Hospital of Guizhou Medical University from August 2018 to July 2019. The XRCC1 rs25487 genotype was detected, followed by neoadjuvant chemoradiotherapy. The logistic regression with adjusted confounding factors was used to analyze the relationship between down-staging of T-stage and N-stage and XRCC1 rs25487 gene polymorphism. The stratified analysis was used to explore interactions of neutrophil lymphocyte ratio (NLR) based on logistic regression. Results The frequencies of all genotypes were in accordance with Hardy-Weinberg equilibrium. After adjusting confounding factors, compared to patients with AA genotype, patients with GG genotype had lower rate of down-staging of T-stage after neoadjuvant radiotherapy (OR=0.1, P<0.05 ). However, there was no statistically significant difference between GA and AA genotypes (P>0.05 ). There was interactions between AA/GA genotypes and NLR, which affected the down-staging of T-stage after radiotherapy. Conclusions XRCC1 rs25487 gene polymorphism is associated with the efficacy of neoadjuvant radiotherapy and concurrent system chemotherapy in patients with LARC, which may be used as a predictor of the efficacy of neoadjuvant intensive therapy. |
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