| Liu Shaoqing,Zheng Baomin,Xiao Shaowen,Xu Xiaolong,Zhao Dan,Liu Weixin,Wang Weihu,Sun Yan.Analysis of prognostic factors affecting brainstem glioma[J].Chinese Journal of Radiological Medicine and Protection,2020,40(8):606-611 |
| Analysis of prognostic factors affecting brainstem glioma |
| Received:December 20, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.08.006 |
| KeyWords:Brainstem glioma Intensity modulated radiotherapy Overall survival Prognostic factors |
| FundProject: |
| Author Name | Affiliation | E-mail | | Liu Shaoqing | Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiation Oncology, Peking University Cancer Hospital&Institute, Beijing 100142, China | | | Zheng Baomin | Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiation Oncology, Peking University Cancer Hospital&Institute, Beijing 100142, China | | | Xiao Shaowen | Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiation Oncology, Peking University Cancer Hospital&Institute, Beijing 100142, China | | | Xu Xiaolong | Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiation Oncology, Peking University Cancer Hospital&Institute, Beijing 100142, China | | | Zhao Dan | Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiation Oncology, Peking University Cancer Hospital&Institute, Beijing 100142, China | | | Liu Weixin | Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiation Oncology, Peking University Cancer Hospital&Institute, Beijing 100142, China | | | Wang Weihu | Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiation Oncology, Peking University Cancer Hospital&Institute, Beijing 100142, China | | | Sun Yan | Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiation Oncology, Peking University Cancer Hospital&Institute, Beijing 100142, China | lsqlsq2009@yeah.net |
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| Abstract:: |
| Objective To explore overall survival(OS) and prognostic factors of brainstem gliomas (BSG) after intensity modulated radiotherapy (IMRT) by a retrospective single-center analysis. Methods A total of twenty-one patients with BSG were collected in the Department of Radiation Oncology, Peking University Cancer Hospital from January 2012 to September 2019. All patients underwent IMRT. OS and potential prognostic factors were analyzed, including gender, age, operation type, imaging classification, tumor location, WHO grade, chemotherapy, radiotherapy pattern, time interval between morbidity and the first treatment, and radiation dose. Results Eighteen of twenty-one patients were followed up more than 3 months. The median follow-up time was 15.5 (5.3-25.6) months. The median overall survival (mOS) was 20 (14.1-25.8) months. The 1 and 2-year OS rates were 86.2% and 34.5% respectively. Operation type, imaging classification, tumor location, WHO grade and radiotherapy pattern were the prognosis factors (χ2=4.829-20.261, P<0.05). Conclusions Patients with maximal safe surgical resection, focal endogenesis/exogenesis, tumor located in mesencephalon, low-grade gliomas and/or received postoperative radiotherapy have a better prognosis. It has certain reference value for guiding the clinical practice. |
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