| Ou Mingqian,Sun Furong,Fan Weihao,Cui Lili,Li Minhua,Lin Meijun,Yu Yangsheng,Liang Shiyun,Zhou Haihong.The research status and prospects of microRNA-glial regulatory network in radiation-induced brain injury[J].Chinese Journal of Radiological Medicine and Protection,2020,40(7):564-569 |
| The research status and prospects of microRNA-glial regulatory network in radiation-induced brain injury |
| Received:November 26, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.07.014 |
| KeyWords:Radiation-induced brain injury microRNA Glial cell Regulatory network |
| FundProject:国家自然科学基金（81501040） |
| Author Name | Affiliation | E-mail | | Ou Mingqian | Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China | | | Sun Furong | Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China | | | Fan Weihao | Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China | | | Cui Lili | Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China | | | Li Minhua | Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China | | | Lin Meijun | Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China | | | Yu Yangsheng | Department of Neurology, Puning People's Hospital, Jieyang 515300, China | | | Liang Shiyun | Department of Otolaryngology, Head and Neck Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China Corresponding | | | Zhou Haihong | Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China | Doctorzhh1201@126.com |
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| Abstract:: |
| Radiation-induced brain injury (RBI) is the most serious complication of head and neck tumor after radiotherapy. The pathogenesis of RBI is complicated, and the clinical course is irreversible, while no effective treatment available. The activation of glial cells is one of the main theories of RBI, and the prevention and treatment of RBI by targeting glial cells is the focus of current research. As a post-transcriptional regulatory factor, microRNA (miRNA) has been confirmed to be involved in regulatingglial cell radiosensitivity, inflammation type transformation, autophagy, exosomatic, long non-coding RNA (lncRNA), circular RNA (circRNA) and other related pathways, thereby mediating the occurrence and development of cascade reaction of inflammatory injury and neurological function repair of central nervous system (CNS) disease. Therefore, the establishment of miRNA-glial regulatory network may provide a new strategy for the prevention and treatment of RBI. |
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