Zhou Yuchuan,Shao Chunlin.Influence of histone modification on cell radiosensitivity[J].Chinese Journal of Radiological Medicine and Protection,2020,40(7):559-563
Influence of histone modification on cell radiosensitivity
Received:December 11, 2019  
DOI：10.3760/cma.j.issn.0254-5098.2020.07.013
KeyWords:Histone modification  DNA repair  Radiation sensitivity
FundProject:国家重点研发计划（2017YFC0108604）；国家自然科学基金（31770910，31570850）
Author NameAffiliationE-mail
Zhou Yuchuan Institution of Radiation Medicine, Fudan University, Shanghai 200032, China  
Shao Chunlin Institution of Radiation Medicine, Fudan University, Shanghai 200032, China clshao@shmu.edu.cn 
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Abstract::
      Histone modification plays an important role in the process of cellular DNA damage repair. In recent years, a great number of studies have shown that histone modification affectsradiation responses including recruitment of DNA damage repair factors, creation of chromatin open structures and establishment of repressive histone marks.Regulation of histone modification may influence the process of DNA damage repair and thus affect radiation sensitivity. In this paper, the effects of histone modification on DNA damage repair,cellular radiosensitivity and the underlying mechanisms are reviewed.
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