| Chen Jun,Zhang Lidong,Chen Leru,Mao Yinghua,Wang Chunhui,Wang Junping,Li Hong.Research progress on medical protective agents for ionizing radiation damage[J].Chinese Journal of Radiological Medicine and Protection,2020,40(7):554-558 |
| Research progress on medical protective agents for ionizing radiation damage |
| Received:September 29, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.07.012 |
| KeyWords:Ionizing radiation Medical protection Free radicals DNA oxidative damage |
| FundProject:国家自然科学基金（81803173）；江苏省自然科学基金（BK20180131） |
| Author Name | Affiliation | E-mail | | Chen Jun | College of Preventive Medicine, Army Medical University, Chongqing 400038, China | | | Zhang Lidong | College of Preventive Medicine, Army Medical University, Chongqing 400038, China | | | Chen Leru | Institute of Medical Protection, Disease Control and Prevention of Eastern Theater Command, Nanjing 210002, China | | | Mao Yinghua | Institute of Medical Protection, Disease Control and Prevention of Eastern Theater Command, Nanjing 210002, China | | | Wang Chunhui | Institute of Medical Protection, Disease Control and Prevention of Eastern Theater Command, Nanjing 210002, China | | | Wang Junping | College of Preventive Medicine, Army Medical University, Chongqing 400038, China | | | Li Hong | Institute of Medical Protection, Disease Control and Prevention of Eastern Theater Command, Nanjing 210002, China | lihong0708@sina.com |
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| Abstract:: |
| Nowadays, ionizing radiation has become one of the risk factors for human healthy. Exploring effective protective strategies are important topics in radiological medicine. Timely using of the radiation protection agents are the most direct and effective medical protective strategy for reducing the damage of ionizing radiation to normal tissues of the body. A large number of new radiation protective agents based on mechanisms such as scavenging of free radicals, promoting DNA damage repair, inducing hypoxia of irradiated tissues and blocking bystander effect have been developed gradually. This review summarizes a variety of radiation protective agents, and their potential molecular biological mechanisms reported in recent years, to provide theoretical reference for exploring novel medical protective agents of ionizing radiation. |
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