| Zhang Yongxia,Yuan Xiangkun,Miao Junjun,Hou Guangying,Chen Yuanyuan,Liu Qiong,Lyu Huanhuan.Dosimetric analysis of 3D-printed minimally invasive-guided template in the brachytherapy treatment of locally advanced cervical cancer[J].Chinese Journal of Radiological Medicine and Protection,2020,40(7):519-523 |
| Dosimetric analysis of 3D-printed minimally invasive-guided template in the brachytherapy treatment of locally advanced cervical cancer |
| Received:February 16, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.07.005 |
| KeyWords:Cervical cancer 3D-printed Intracavitary Interstitial Dosimetry |
| FundProject: |
| Author Name | Affiliation | E-mail | | Zhang Yongxia | Department of Radiotherapy and Chemotherapy, Hebei Cangzhou Hospital of Intergrated Traditional Chinese Medicine and Western Medicine, Cangzhou 061000, China | | | Yuan Xiangkun | Department of Radiotherapy and Chemotherapy, Hebei Cangzhou Hospital of Intergrated Traditional Chinese Medicine and Western Medicine, Cangzhou 061000, China | yuanxiangkun@126.com | | Miao Junjun | Department of Radiotherapy and Chemotherapy, Hebei Cangzhou Hospital of Intergrated Traditional Chinese Medicine and Western Medicine, Cangzhou 061000, China | | | Hou Guangying | Department of Radiotherapy and Chemotherapy, Hebei Cangzhou Hospital of Intergrated Traditional Chinese Medicine and Western Medicine, Cangzhou 061000, China | | | Chen Yuanyuan | Department of Radiotherapy and Chemotherapy, Hebei Cangzhou Hospital of Intergrated Traditional Chinese Medicine and Western Medicine, Cangzhou 061000, China | | | Liu Qiong | Department of Radiotherapy and Chemotherapy, Hebei Cangzhou Hospital of Intergrated Traditional Chinese Medicine and Western Medicine, Cangzhou 061000, China | | | Lyu Huanhuan | Department of Radiotherapy and Chemotherapy, Hebei Cangzhou Hospital of Intergrated Traditional Chinese Medicine and Western Medicine, Cangzhou 061000, China | |
|
| Hits: 2576 |
| Download times: 1042 |
| Abstract:: |
| Objective To investigate the dosimetry advantage of 3D-printed minimally invasive guided template used in local advanced cervical cancer intracavitary combined with interstitial radiotherapy. Methods A total of 68 cases with locally advanced cervical cancer who were admitted to Hebei Cangzhou Hospital of intergrated traditional Chinese medicine and western medicine from May 2016 to August 2019 were selected. All the patients had eccentric tumor or large tumor (tumor diameter >5 cm) after radiotherapy. Intensity modulated radiotherapy was used for external radiotherapy, and intracavitary combined with interstitial radiotherapy was used for brachytherapy. The prescription dose of high-risk clinical target volume (HR-CTV) is 6 Gy/fraction, once a week, five fractions in total. Sixty-eight patients were randomly divided into two groups, 35 cases in the template group who received minimally invasive 3D printing guided template assisted intrauterine tube implantation and insertion needle implantation, and 33 patients in the free implantation group who received free hand intrauterine tube implantation and insertion needle implantation. The position and depth of the insertion needle were adjusted by CT-guidance, and the final CT image was transmitted to the Oncentra Brachy treatment planning system, then the target volume and organs at risk were delineated for planning and treatment. Results A total of 340 brchytherapy plans were made, including 175 in the template group and 165 in the free implantation group. The D90 values of the HR-CTV and intermediate-risk clinical target volume (IR-CTV) in the template group were increased (t=3.63, 2.45, P<0.05), and D2 cm3 values (dose of 2 cm3 of organ at risk) of bladder, rectum and sigmoid colon were significantly decreased (t=-2.81, -2.54, -2.33, P<0.05). At the same time, the average CT scanning times of each treatment in the template group was (1.78±0.53) times, the average duration of each treatment was (11.35±3.98) min, and the average number of needles used in each implant treatment was (5.21±1.37). The result of free implantation group was higher than that of the template group. The differences were statistically significant (t=-2.26, -4.53, -3.21, P<0.05). Conclusions For localized advanced cervical cancer patients with eccentric or large tumors, the 3D printed minimally invasive guided template for intracavitary and interstitial implantation has obvious dosimetry advantages, and the operation is simpler and the duration is shorter. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
