| Guan Xiyin,Gao Jing,Hu Jiyi,et al.The preliminary result of proton and carbon ion therapy for recurrent chordoma and chondrosarcoma of skull base and cervical spine[J].Chinese Journal of Radiological Medicine and Protection,2020,40(6):434-438 |
| The preliminary result of proton and carbon ion therapy for recurrent chordoma and chondrosarcoma of skull base and cervical spine |
| Received:July 13, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.06.004 |
| KeyWords:Chordoma Chondrosarcoma Proton Carbon ion Radiotherapy |
| FundProject:上海市市级医院新兴前沿技术联合攻关项目（SHDC12016120）；上海市科技创新行动计划（19411951000） |
| Author Name | Affiliation | E-mail | | Guan Xiyin | Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201321, China | | | Gao Jing | Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201321, China | | | Hu Jiyi | Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201321, China | | | Hu Weixu | Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201321, China | | | Yang Jing | Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201321, China | | | Hu Chaosu | Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 200032, China | | | Kong Lin | Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 200032, China | lin.kong@sphic.org.cn | | Lu Jiade | Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201321, China | |
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| Abstract:: |
| Objective To evaluate the short-term tumor control and toxicity of recurrent skull base and cervical spine chordoma and chondrosarcoma in patients treated with pencil beam scanning proton and heavy ion therapy. Methods Between June 30th, 2014 and July 30th, 2018, a total of 45 skull base and cervical spine chordoma (n=39) and chondrosarcoma (n=6) patients (28 males and 17 females; mean age at initial presentation of 44 years, range, 14-76 years) were treated in our center for the course of radiotherapy. The median maximum tumor volume was 57 cm3 (range, 6.6-231.7 cm3). There were 31 post-operative recurrent patients and 14 post-operative and post-radiated recurrent patients. One patient received proton therapy, 21 patients received combined proton and carbon ion therapy, 23 patients received carbon ion therapy. Results All patients completed the whole course of the treatment. The median follow-up time was 29 months (range:8-57 months), the 2-year overall survival (OS), local control (LC), and progression-free survival (PFS) were 82.7%, 85.3%, and 73.8%, respectively. There were no other grade 3-4 acute or late radiation-induced toxicity except one grade 3 acute mucositis. The 2-year OS rates for patients after first-time radiation vs. re-irradiation were 96.2% and 50.3% (χ2=16.969, P<0.05). Conclusions The short-term outcomes of pencil beam scanning proton and heavy ion therapy for recurrent skull base and cervical spine chordoma and chondrosarcoma is favorable. Further study is needed for long-term efficacy and safety. |
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