| Sun Dan,Zhang Guorong.Strategies and progresses of stereotactic radiosurgery for intractable brain metastases[J].Chinese Journal of Radiological Medicine and Protection,2020,40(5):408-412 |
| Strategies and progresses of stereotactic radiosurgery for intractable brain metastases |
| Received:January 17, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.05.014 |
| KeyWords:Brain metastases Multiple brain metastases Recurrent brain metastases Stereotactic radiosurgery |
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| Abstract:: |
| Brain metastases are common intracranial diseases featured with high incidence rate, difficult clinical treatment and poor prognosis. Especially for refractory brain metastases (large volume, multiple recurrence and metastatic tumors), it is difficult for conventional therapies to achieve ideal prognosis. Compared with conventional therapies, stereotactic radiosurgery (SRS) has the advantages of high accuracy, large fractional dose and low damage to the surrounding tissues, and has gradually become the primary choice for the treatment of brain metastases. SRS has a good effect in the treatment of refractory brain metastases, and can effectively inhibit tumor proliferation and improve the quality of life of patients. SRS combined with surgery, chemotherapy, molecular targeted therapy and immunotherapy can improve the local tumor control rate of patients with intractable brain metastasis, but whether it can improve the prognosis of patients is still controversial. The adverse reactions of combined therapies should also be concerned. Therefore, this article reviews the therapeutic effects of SRS in the treatment of refractory brain metastases, the strategies and progresses of combined treatment. |
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