| Qi Fei,Chai Yue,Wei Yuce,et al.Different treatment modalities for patients with early stage extranodal NK/T-cell lymphoma: A retrospective comparative study based on the SEER database[J].Chinese Journal of Radiological Medicine and Protection,2020,40(5):372-378 |
| Different treatment modalities for patients with early stage extranodal NK/T-cell lymphoma: A retrospective comparative study based on the SEER database |
| Received:January 21, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.05.008 |
| KeyWords:Extranodal NK/T-cell lymphoma Chemoradiotherapy Combined treatment Surrival benefit Surveillance, epidemiology and end results database |
| FundProject: |
| Author Name | Affiliation | E-mail | | Qi Fei | Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China | | | Chai Yue | Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China | | | Wei Yuce | Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China | | | Dong Mei | Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China | dongmei030224@163.com |
|
| Hits: 3347 |
| Download times: 1789 |
| Abstract:: |
| Objective To explore the effectiveness of the treatment modality among western localized extranodal NK/T-cell lymphoma (ENKTCL) patients based on the Surveillance, Epidemiology and End Result (SEER) database. Methods A total of 448 cases of early stage ENKTCL, diagnosed from 2000 to 2016, were identified from the SEER database:108 received chemotherapy alone, 100 received radiation alone, and 240 had combined chemoradiotherapy. Overall survival (OS) were compared between different modalities using univariate, multivariate and propensity-score matched (PSM) method. Results The median overall survival (OS) and 5-year OS rate were 59.0 months and 49.0% for the whole cohort, respectively. Different treatment modalities were significantly associated with OS of patients with localized ENKTCL. Patients who received chemoradiotherapy had the highest 5-year OS rate followed by those who received radiation alone and chemotherapy alone (62.1% vs. 41.5% vs. 28.5%, χ2=41.727,P<0.001). Patients who received radiation with/without chemotherapy had significant superior survival outcome compared with those who received chemotherapy alone (5-year OS rate, 55.9% vs. 28.5%, χ2=10.823,P<0.001). Furthermore, compared with radiation alone, additional chemother-apy to radiation provided survival benefit and reduced death hazard for localized ENKTCL (HR 0.578, 95% CI:0.413~0.808, P=0.001). After baseline prognostic factors adjustment using PSM method, similar survival benefit was still observed among patients treated with chemoradiotherapy over those treated with radiation alone (5-year OS, 61.3% vs. 40.5%, HR 0.592, 95% CI:0.369~0.885, P=0.012). Conclusions These results based on SEER database indicate that compared with radiation or chemotherapy alone, chemoradiotherapy is more preferable treatment option for patients with early stage ENKTCL. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
