| Tang Ying,Su Shibiao,Jin Yali,Lin Haihui,Wen Cuiju,Tan Weijun.Investigation on the levels of interleukins and TGF-β1 in the population in natural high background area[J].Chinese Journal of Radiological Medicine and Protection,2020,40(5):349-354 |
| Investigation on the levels of interleukins and TGF-β1 in the population in natural high background area |
| Received:October 28, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.05.004 |
| KeyWords:High background radiation Interleukin Adaptive response |
| FundProject:国家自然科学基金青年科学基金项目（81602804） |
| Author Name | Affiliation | E-mail | | Tang Ying | Academy of Public Health of Guangdong Pharmaceutical University, Guangzhou 510310, China | | | Su Shibiao | Evaluation Institute of Guangdong Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China | | | Jin Yali | Laboratory of Molecular Epidemiology of the Twelfth People's Hospital of Guangzhou, Guangzhou 510006, China | | | Lin Haihui | Evaluation Institute of Guangdong Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China | | | Wen Cuiju | Evaluation Institute of Guangdong Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China | | | Tan Weijun | Academy of Public Health of Guangdong Pharmaceutical University, Guangzhou 510310, China | weijunt0726@163.com |
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| Abstract:: |
| Objective To investigate the effect of long-term low dose ionizing radiation on the levels of interleukin (IL) and TGF-β1 in the population in high background radiation area(HBRA). Methods Appropriate amount of peripheral blood was drawn from 41 and 44 healthy men aged 45-65 years who were randomly selected from Tangkou town of Yangjiang city (HBRA) and Hengpo town of Enping city (control area, CA), respectively. After centrifugation and stratification, the upper plasma of blood was separated to determine IL-2, sIL-2R, IL-4, IL-5 and TGF-β1 by using ELISA. The difference of plasma IL of the residents in those two regions was analyzed. The influence of region, age, smoking, drinking and income on the indexes of ILs and TGF-β1 was evaluated by Covariance analysis. Results The concentration of IL-2 at HBRA area was slightly higher than those in the control area, but the other indexes were lower than those in CA residents. The differences of IL-5 (t=7.124, P<0.001) and TGF-β1 (t=4.900, P<0.001) between two areas were significant statistically. Covariance analysis showed that smoking had a significant effect on IL-2 level (F=5.283,P<0.05). Conclusions Under the influence of long-term low-dose ionizing radiation, all kinds of plasma interleukin levels of residents in HBRA were different with that in CA. The immune balance was biased towards Th1 type cytokines, and the immune function in HBRA was slightly stronger than that in CA, suggesting that long-term chronic low-dose ionizing radiation may induce adaptive changes in the immune function, which needs further study. |
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