| Zhu Yadi,Wu Ailin,Liu Yunqin,et al.Application of three different kinds of local boost techniques in radiotherapy for locally advanced cervical cancer[J].Chinese Journal of Radiological Medicine and Protection,2020,40(4):296-301 |
| Application of three different kinds of local boost techniques in radiotherapy for locally advanced cervical cancer |
| Received:May 21, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.04.009 |
| KeyWords:Locally advanced cervical cancer Brachytherapy Intensity modulated radiotherapy Intracavitary/interstitial brachytherapy Dosimetry |
| FundProject:国家自然科学基金（11805198）；安徽省自然科学基金青年项目（1808085QH281） |
| Author Name | Affiliation | E-mail | | Zhu Yadi | College of Biomedical Engineering, Anhui Medical University, Hefei 230032, China | | | Wu Ailin | Department of Radiation Oncology, First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, China | | | Liu Yunqin | Department of Radiation Oncology, First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, China | | | Xue Xudong | Department of Radiation Oncology, First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, China | | | Zhang Peng | Department of Radiation Oncology, First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, China | | | Wu Aidong | Department of Radiation Oncology, First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, China | flkaidongwu@163.com |
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| Abstract:: |
| Objective To investigate the dosimetry differences in the treatment of locally advanced cervical cancer with intracavitary/interstitial brachytherapy (IC/IS BT), intracavity brachytherapy combined with intensity modulated radiotherapy (ICBT+IMRT) and simple IMRT. Methods Totally 16 patients with local advanced cervical cancer were retrospectively selected, which were treated by three-dimensional brachytherapy. On the basis of the original three-dimensional intracavitary/interstitial brachytherapy plan, ICBT+IMRT and IMRT plans were designed respectively to study the dosimetry differences of target and different organs at risk for the three kinds of plans. Results A total of 75 brachytherapy treatment plans were designed, including 25 IC/IS BT, 25 ICBT+IMRT and 25 IMRT. There was not statistically significant difference of target dose parameters between ICBT+IMRT and IC/IS BT plan (P>0.05). ICBT+IMRT plans had better OAR sparing than IC/IS BT. The doses of OARs in the IMRT plans were relatively large and the volume irradiated to more than 60 Gy (V60) was significantly higher(t=6.77,10.37,4.61,2.83,P<0.05). Conclusions The ICBT+IMRT technique not only provides better target coverage, but also maintains low doses to the OARS, which can be used as an alternative treatment to IC/IS BT. Although the target coverage of IMRT is better, the protection of OARs is not satisfied, so it is not suitable for local boost therapy of advanced cervical cancer. |
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