| Li Shuang,Lu Xue,Chen Deqing,et al.Study on the feasibility of dose estimation by the dose-response curves based on different types of dicentrics[J].Chinese Journal of Radiological Medicine and Protection,2020,40(4):273-277 |
| Study on the feasibility of dose estimation by the dose-response curves based on different types of dicentrics |
| Received:November 18, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.04.005 |
| KeyWords:Chromosome aberration Dose-response curves Dicentric Ionizing radiation |
| FundProject:国家自然科学基金（81803162，81573081） |
| Author Name | Affiliation | E-mail | | Li Shuang | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Lu Xue | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Chen Deqing | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Liu Qingjie | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | liuqingjie@nirp.chinacdc.cn |
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| Abstract:: |
| Objective To investigate the feasibility of dose estimation based on the dose-response curves established by different types of dicentrics (dic). Methods Human peripheral blood samples were irradiated by 60Co γ-rays at the doses of 0, 0.5, 1, 2, 3, 4, 5 and 6 Gy with the dose rate of 0.27 Gy/min, and chromosome preparation was carried out. The different types of dics were analyzed. The dose-response curves were fitted with software of Chromosomal Aberration Calculation Software (CABAS). Two samples were used to validate the dose-response curves. Results The aberration rates of different types of dics increased with the exposure doses (R2=0.886-0.943,P<0.01).The proportion of typical and single-ended dic components accounted for more than 92% of all types of dic, while the proportion of short-range dic and double-ended dic components was less than 4% at each dose point. The dose-response curves based on different types of dics were established (R2=0.998, P<0.01). There was no significant difference in the doses estimated by four different dose-response curves (P>0.05). The relative deviations between actual and predict doses were less than 13.08% by using dose-response curve based on typical dics. Conclusions Dose-response curves based on different types of dics have the feasibility of dose estimation. |
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