| Wang Haiyang,Wu Hao,Xiang Xiaoyu,Huang Yuliang,Li Chenguang,Hu Qiaoqiao,Du Yixiao,Gong Jian,Li Weibo,Zhang Yibao.A feasibility study of local adaptation of Lung SBRT RapidPlan commercial model[J].Chinese Journal of Radiological Medicine and Protection,2020,40(3):203-208 |
| A feasibility study of local adaptation of Lung SBRT RapidPlan commercial model |
| Received:July 10, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.03.008 |
| KeyWords:Radiotherapy planning RapidPlan Localize Lung cancer Stereotactic body radiation therapy |
| FundProject:首都卫生发展科研专项（首发2018-4-1027）；教育部科技发展中心产学研创新基金-"智融兴教"基金（2018A01019）；国家自然科学基金（11505012，11905150）；国家重点研发计划（2019YFF01014405）；四川省科技计划（2018HH0099）；北京市自然科学基金（7172048）；北京市属医院科研培育计划项目（PX2019042） |
| Author Name | Affiliation | E-mail | | Wang Haiyang | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Wu Hao | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Xiang Xiaoyu | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Huang Yuliang | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Li Chenguang | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Hu Qiaoqiao | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Du Yixiao | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Gong Jian | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Li Weibo | Institute of Radiation Medicine, Helmholtz Zentrum Mü
nchen-German Research Center for Environmental Health(GmbH), Ingolstä
dter Landstr. Neuherberg 185764, Germany | | | Zhang Yibao | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | ybzhang66@163.com |
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| Abstract:: |
| Objective To explore the feasibility and optimization effect of modifying the Henry Ford Hospital (HFHS) RapidPlan model for stereotactic body radiation therapy planning based on local requirements. Methods The following changes were made based on Henry Ford Health System(HFHS) Rapid Plan Lung SBRT model, taking the latest clinical guideline evidence and local clinical practice into account:Internal gross target volume(IGTV) and organ at risk(OAR) structure, lung, were added and set corresponding parameters.The upper value of planning target volume (PTV) was adjusted from 109% to 125%. The original training library was replaced with 73 local historical simultaneous integrated boosting plans, and statistical verification and outlier cleaning of the initial trained model were performed using Model Analytics software. Totally 10 cases not included in the model library were selected for independent verification, and automatic optimization result of the models before and after modifying were compared under the same beam condition. The following dosimetric parameters were compared after target dose normalization:conformal index (CI) of target volume, the mean doses, maximum doses and dose-volume parameters of OARs. Results The "tail" of the PTV's DVH and the "shoulder"and "tail" of the IGTV's DVH of model M(local) validation plan (M(local)_P) performs higher than the original model HFHS (HFHS_P). The PTV_CI (1.07±0.13) of Mlocal_P were significantly smaller than HFHS_P (1.25±0.24) (Z=-2.497, P<0.05). Except for Heart_D15 cm3 and Heart_Dmax, most of the Mlocal_P dosimetric parameters of OARs were lower than HFHS_P, and the standard deviation was smaller. However, the difference of between two plans was no more than 3.06%. 10 HFHS_P plans don't satisfy dose parameters requirement, two of which PTV_CI values are 1.52 and 1.74, far beyond the clinically acceptable range. Conclusions Commercial model HFHS could be localized by replacing training library and adjusting parameters. Moreover, plans optimized by the modified model are local clinical acceptable in the aspects of target volume conformity and hotspots, and have a better performance in terms of OAR sparing and plan consistency. |
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