| Lu Xue,Zhao Hua,Wang Jin,Li Shuang,Tian Xuelei,Wang Furu,Tian Mei,Yu Ningle,Liu Qingjie.Cytogenetic analysis of the victim followed-up at 4 year after 192Ir radiation accident in Nanjing[J].Chinese Journal of Radiological Medicine and Protection,2020,40(3):183-188 |
| Cytogenetic analysis of the victim followed-up at 4 year after 192Ir radiation accident in Nanjing |
| Received:June 05, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.03.005 |
| KeyWords:Chromosome aberration Fluorescence in situ hybrdization G banding Biological dose estimation Correction coefficient |
| FundProject: |
| Author Name | Affiliation | E-mail | | Lu Xue | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention
China CDC Key Laboratory of Radiological Protection and Nuclear Emergency
WHO Collaborating Center for Radiation and Health(No. CHN-145), Beijing 100088, China | | | Zhao Hua | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention
China CDC Key Laboratory of Radiological Protection and Nuclear Emergency
WHO Collaborating Center for Radiation and Health(No. CHN-145), Beijing 100088, China | | | Wang Jin | Department of Radiation Protection, Jiangsu Provincial Center of Disease Control and Prevention, Nanjing 210009, China | | | Li Shuang | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention
China CDC Key Laboratory of Radiological Protection and Nuclear Emergency
WHO Collaborating Center for Radiation and Health(No. CHN-145), Beijing 100088, China | | | Tian Xuelei | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention
China CDC Key Laboratory of Radiological Protection and Nuclear Emergency
WHO Collaborating Center for Radiation and Health(No. CHN-145), Beijing 100088, China | | | Wang Furu | Department of Radiation Protection, Jiangsu Provincial Center of Disease Control and Prevention, Nanjing 210009, China | | | Tian Mei | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention
China CDC Key Laboratory of Radiological Protection and Nuclear Emergency
WHO Collaborating Center for Radiation and Health(No. CHN-145), Beijing 100088, China | | | Yu Ningle | Department of Radiation Protection, Jiangsu Provincial Center of Disease Control and Prevention, Nanjing 210009, China | | | Liu Qingjie | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention
China CDC Key Laboratory of Radiological Protection and Nuclear Emergency
WHO Collaborating Center for Radiation and Health(No. CHN-145), Beijing 100088, China | liuqingjie@nirp.chinacdc.cn |
|
| Hits: 2751 |
| Download times: 1032 |
| Abstract:: |
| Objective To screen the indicators of retrospective dose estimation, based on 5 cytogenetic methods to assess the victim followed-up at 4 year after 192Ir radiation accident in Nanjing. Methods The chromosome aberration (dic + r) assay, cytokinesis block micronucleus (MN) and nucleoplasmic bridge (NPB) assay, fluorescence in situ hybridization (FISH)-based and G banding-based translocation analysis were used to retrospective biological dose estimation. Results The estimated doses of FISH-based and G banding -based analysis were 1.45 and 1.21 Gy respectively, which was similar to the biological dose estimated short time after the accident. However, the estimated doses by chromosome aberration, micronucleus and nucleoplasmic bridge method were 0.56, 0.45 and 0.41 Gy respectively, which were lower than the corresponding biodose. Correction factors were used to adjust the biodose. Conclusions In the 4th years after exposure, the estimated biological doses by FISH-based and G banding-based translocation were consistent with the biodose.Therefore, the two methods were suitable for retrospective dose estimation, while correction factors should be considered in chromosome aberration method for retrospective dose estimation. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
