| Zhao Hongli,Chen Ying,Wang Xiaoyong,et al.An integrated design of fields in IMRT for post-radical mastectomy[J].Chinese Journal of Radiological Medicine and Protection,2020,40(2):116-121 |
| An integrated design of fields in IMRT for post-radical mastectomy |
| Received:August 15, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.02.008 |
| KeyWords:Post-radical mastectomy Intensity-modulated radiation therapy OARS Long-term cardiac disease Clinical application |
| FundProject: |
| Author Name | Affiliation | E-mail | | Zhao Hongli | Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan 430071, China | | | Chen Ying | Department of Radiation Oncology, Jingmen NO. 2 People's Hospital, Jingmen 448000, China | | | Wang Xiaoyong | Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan 430071, China | wangxiaoyong@znhospital.cn | | Zhang Hongyan | Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan 430071, China | | | Zhong Yahua | Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan 430071, China | | | Liu Hui | Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan 430071, China | |
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| Abstract:: |
| Objective To investigate the dosimetry differences of target and OARs of an integrated design of fields in IMRT and the mainstream IMRT technique for post-radical mastectomy. Methods A total of 41 patients with post-radical mastectomy who received IMRT were eligible, the conventional fixing two-degrade collimator and the integrated IMRT fields were designed respectively. The dosimetry parameters of target and OARs, monitor units and delivery time of both plans were compared. Results The dose distribution for targets and OARs of both plans met clinical requirements. The dosimetry parameters of target of both plans showed no statistically significant difference (P>0.05). Compared with the conventional technique, the integrated IMRT plans showed significant advantages, the ipsilateral lung V5 decreased by 9.7%(t=2.407,P<0.05),V10 11.2%(t=2.160,P<0.05),V20 17.3%(t=2.465,P<0.05),V30 13.4%(t=2.119,P<0.05),Dmean 13.8%(t=2.258,P<0.05). And the heart V30 decreased by 28.4%(t=2.589,P<0.05),Dmean 23.2%(t=2.409,P<0.05). The dosimetric differences of other OARS were not statistically significant(P>0.05). Conclusions The new method can effectively reduce exposed volume and exposed dose of ipsilateral lung and heart without affecting the target dose coverage. The method has universal applicability to patients with post-radical mastectomy who received IMRT, with important clinical significance. |
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