| Li Shan,Wang Xuezheng,Chen Yanbin,et al.The efficacy of gradeⅡ glioma with postoperative intensity modulated radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2020,40(2):112-115 |
| The efficacy of gradeⅡ glioma with postoperative intensity modulated radiotherapy |
| Received:August 28, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.02.007 |
| KeyWords:Grade Ⅱ glioma Intensity modulated radiotherapy Efficacy Prognosis |
| FundProject:山东省重点研发计划（2018GSF118006） |
| Author Name | Affiliation | E-mail | | Li Shan | Department of Radiation Oncology, First Affiliated Hospital of Fujian Medical University, Fujian Key Laboratory of Individualized Active Immunotherapy, Key Laboratory of Radiation Biology(Fujian Medical University), Fuzhou 350005, China | | | Wang Xuezheng | First Clinical Medical College of Fujian Medical University, Fuzhou 350005, China | | | Chen Yanbin | Department of Radiation Oncology, First Affiliated Hospital of Fujian Medical University, Fujian Key Laboratory of Individualized Active Immunotherapy, Key Laboratory of Radiation Biology(Fujian Medical University), Fuzhou 350005, China | | | Wu Zanyi | Department of Neurosurgery, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China | | | Zhang Hairong | Provincial Center for Disease Control and Prevention, Fuzhou 350005, China | | | Zeng Jiang | Department of Radiation Oncology, First Affiliated Hospital of Fujian Medical University, Fujian Key Laboratory of Individualized Active Immunotherapy, Key Laboratory of Radiation Biology(Fujian Medical University), Fuzhou 350005, China | | | Cai Chuanshu | Department of Radiation Oncology, First Affiliated Hospital of Fujian Medical University, Fujian Key Laboratory of Individualized Active Immunotherapy, Key Laboratory of Radiation Biology(Fujian Medical University), Fuzhou 350005, China | | | Zhang Weijian | Department of Radiation Oncology, First Affiliated Hospital of Fujian Medical University, Fujian Key Laboratory of Individualized Active Immunotherapy, Key Laboratory of Radiation Biology(Fujian Medical University), Fuzhou 350005, China | | | Su Li | Department of Radiation Oncology, First Affiliated Hospital of Fujian Medical University, Fujian Key Laboratory of Individualized Active Immunotherapy, Key Laboratory of Radiation Biology(Fujian Medical University), Fuzhou 350005, China | | | Hong Jinsheng | Department of Radiation Oncology, First Affiliated Hospital of Fujian Medical University, Fujian Key Laboratory of Individualized Active Immunotherapy, Key Laboratory of Radiation Biology(Fujian Medical University), Fuzhou 350005, China | hjs703@126.com |
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| Abstract:: |
| Objective To retrospectively analyze the efficacy and prognostic factors of postoperative intensity modulated radiotherapy for grade Ⅱ gliomas. Methods Retrospective analysis was conducted on patients with postoperative grade Ⅱ glioma in our hospital from Jan. 2010 to Dec. 2018. The primary endpoint was progression-free survival, and the secondary endpoint was overall survival. Correlative analyses of prognosis by age, gender, initial resection status, the maximum diameter of the lesions, bi-hemisphere, astrocytoma, chemoradiation, adjuvant chemotherapy were conducted. Results A total of 109 cases with grade Ⅱ glioma were enrolled. The follow-up rate was 91.75%, including 10 cases dead and 27 relapsed. There were 24 cases (88.9%) of in-field failure,and 3 cases (11.1%) of out-field failure. 14 cases of recurrence occurred in 81 cases of total resection group, accounting for 17.3%, and 13 in 28 cases of subtotal resection group, accounting for 46.4%. The recurrence rate in the subtotal resection group was significantly higher than that in the total resection group (χ2=9.484, P<0.05). The 1-, 2-, 3-, 4- and 5-year progression-free survival rates were 92.5%, 86.0%, 80.6%, 77.5% and 66.8%, respectively. The 2-, 3-, 4- and 5-year overall survival rates were 97.2%, 90.8%, 87.7% and 84.5%, respectively. Multivariate analysis showed that patients with subtotal resection(HR=3.608,P<0.05) and bi-hemisphere(HR=3.183,P<0.05)were significantly correlated with the progression free survival. Conclusions Postoperative intensity modulated radiotherapy for grade Ⅱ gliomas can achieve a better PFS. Recurrence in the radiation field is the main failure mode. Initial resection status and bi-hemisphere of tumor are important influential factors for PFS of grade Ⅱ gliomas patients. |
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