| Yin Xiaoming,Sun Yunchuan,Hu Tingting,He Xinying,Bi Jianqiang,Xiao Li,Huang Rujing,Lu Hongling,Wang Junjie.Preliminary application of 192Ir high-dose rate brachytherapy in postoperative recurrent colorectal cancer with intrapulmonary oligometastases[J].Chinese Journal of Radiological Medicine and Protection,2019,39(11):833-836 |
| Preliminary application of 192Ir high-dose rate brachytherapy in postoperative recurrent colorectal cancer with intrapulmonary oligometastases |
| Received:March 26, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2019.11.006 |
| KeyWords:Colorectal cancer Lung metastasis High dose ratebrachytherapy 192Ir |
| FundProject: |
| Author Name | Affiliation | E-mail | | Yin Xiaoming | Department of Radiation Oncology, Cangzhou Integrated Traditional Chinese and Western Medicine Hospital, Cangzhou 061000, China | | | Sun Yunchuan | Department of Radiation Oncology, Cangzhou Integrated Traditional Chinese and Western Medicine Hospital, Cangzhou 061000, China | 13932719095@163.com | | Hu Tingting | Department of Radiation Oncology, Cangzhou Integrated Traditional Chinese and Western Medicine Hospital, Cangzhou 061000, China | | | He Xinying | Department of Radiation Oncology, Cangzhou Integrated Traditional Chinese and Western Medicine Hospital, Cangzhou 061000, China | | | Bi Jianqiang | Department of Radiation Oncology, Cangzhou Integrated Traditional Chinese and Western Medicine Hospital, Cangzhou 061000, China | | | Xiao Li | Department of Radiation Oncology, Cangzhou Integrated Traditional Chinese and Western Medicine Hospital, Cangzhou 061000, China | | | Huang Rujing | Department of Radiation Oncology, Cangzhou Integrated Traditional Chinese and Western Medicine Hospital, Cangzhou 061000, China | | | Lu Hongling | Department of Radiation Oncology, Cangzhou Integrated Traditional Chinese and Western Medicine Hospital, Cangzhou 061000, China | | | Wang Junjie | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | |
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| Abstract:: |
| Objective To investigate the efficacy and feasibility of 192Ir high-dose rate brachytherapy for recurrent intrapulmonary oligometastasis after colorectal cancer surgery. Methods Patients from May 2013 to October 2017 with intrapulmonary oligometastasisafter colorectal cancer surgery in Cangzhou Integrated Traditional Chinese and Western Medicine Hospital were enrolled. A total of 15 lesions were obtained from 10 patients, which were treated with CT-guided high dose rate of 192Ir. The implant needles were inserted into the tumor and were adjusted to appropriate positions under the guidance of CT. Then the images after transplanting were uploaded to the planning system to delineate the target area and the organ at risk volume. Patients underwent a single radiation dose of 20 Gy. Results All 10 patients were successfully treated. Grade 1 adverse events were observed for 30% of patients. Of the 10 patients, one patient had a mild cough, and two had bloody sputum. There was no serious adverse events occurred. The local control rate (LC) of the patients at 1 year after treatment was achieved in 93.3%. Only one developed local advancement after six months, who received the secondary brachytherapy. The median progression-free survival(PFS) was 8.5 months and the median overall survival(OS) was 14.7 months. Conclusions High dose rate brachytherapy is effective in terms of recurrent lung metastases after surgery for colorectal cancer, with a moderate rate of adverse reactions and a favorable local tumor control rate. |
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