| Jiang Hang,Jin Feng,Wu Weili,Li Yuanyuan,Long Jinhua,Gong Xiuyun,Chen Xiaoxiao,Gan Jiaying,Li Zhuoling.Short-term efficacy and adverse events of intensity-modulated radiotherapy combined with chronomodulated chemotherapy for locally advanced nasopharyngeal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2019,39(11):813-819 |
| Short-term efficacy and adverse events of intensity-modulated radiotherapy combined with chronomodulated chemotherapy for locally advanced nasopharyngeal carcinoma |
| Received:May 27, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2019.11.003 |
| KeyWords:Nasopharyngeal carcinoma Chronomodulated chemotherapy Intensity-modulated radiotherapy Adverse events Short-term efficacy |
| FundProject:贵州省科技厅社发攻关项目黔科合SY字〔2015〕3049 |
| Author Name | Affiliation | E-mail | | Jiang Hang | Department of Oncology of The Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China | | | Jin Feng | Department of Oncology of The Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China | jinf8865@yeah.net | | Wu Weili | Department of Oncology of The Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China | | | Li Yuanyuan | Department of Oncology of The Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China | | | Long Jinhua | Department of Oncology of The Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China | | | Gong Xiuyun | The Affiliated Cancer Hospital of Guizhou Medical University, Department of Head and Neck Oncology/Guizhou Cancer Hospital, Guiyang 550004, China | | | Chen Xiaoxiao | Department of Oncology of The Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China | | | Gan Jiaying | Department of Oncology of The Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China | | | Li Zhuoling | Department of Oncology of The Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China | |
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| Abstract:: |
| Objective To compare the adverse events, immune status, and short-term efficacy between chronomodulated chemotherapy (CCR) and routine chemotherapy (RCR) combined with intensity modulated radiotherapy (IMRT)in the treatment of patients with locally advanced nasopharyngeal carcinoma. Methods A total of 159 patients with newly diagnosed locally advanced nasopharyngeal carcinoma were randomized into the CCR group and the RCR group to evaluate the short-term efficacy and adverse events. Results No significant difference was found in CR, PR,SD, and PD between the CCR group and the RCR group (P>0.05), and no significant difference was observed in the response rate (CR+PR) between the two groups (P>0.05). The incidence of leukopenia(Z=-2.222, P<0.05), neutropenia(Z=-1.999,P<0.05), vomiting(Z=-2.298, P<0.05), and oral mucositis(Z=-3.571, P<0.05)of the CCR group was lower than those of the RCR group with statistical significance. The CD16+56+ lymphocyte cell count was higher in the CCR group than that in the RCR group(Z=-2.332,P<0.05). Conclusions As a novel invention, CCR combined with IMRT can reduce the incidence and severity of treatment-related adverse events and improve immune status without diminishing clinical efficacy, therefore deserving clinical application. |
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