| Xing Ying,Wang Weiwei,Kambiz Shahnazi,Hu Weixu,Hu Jiyi,Gao Jing,Kong Lin,Lu Jiade.Dosimetric study of carbon ion radiotherapy for treating tumors at lacrimal system[J].Chinese Journal of Radiological Medicine and Protection,2019,39(9):686-690 |
| Dosimetric study of carbon ion radiotherapy for treating tumors at lacrimal system |
| Received:March 06, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2019.09.009 |
| KeyWords:Lacrimal system tumor Dosimetry Carbon ion Radiotherapy |
| FundProject:国家自然科学基金（11775145） |
| Author Name | Affiliation | E-mail | | Xing Ying | Department of Medical Physics, Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201315, China | | | Wang Weiwei | Department of Medical Physics, Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201315, China | weiwei.wang@sphic.org.cn | | Kambiz Shahnazi | Department of Medical Physics, Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201315, China | | | Hu Weixu | Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201315, China | | | Hu Jiyi | Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201315, China | | | Gao Jing | Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201315, China | | | Kong Lin | Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201315, China | | | Lu Jiade | Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201315, China | |
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| Abstract:: |
| Objective To evaluate the dosimetric difference between carbon ion radiotherapy and photon radiotherapy for treating tumors at lacrimal system. Methods Using the CT images of 10 patients with tumors at lacrimal system, the carbon ion plan, the photon volume intensity modulation plan (VMAT) and the fixed wild photon intensity modulation radiotherapy (IMRT) plan were generated. The prescription was 54 Gy(RBE) in 18 fractions for clinical target volume (CTV) and 63 Gy(RBE) in 18 fractions for CTV-boost. Dosimetric differences of organ at risks were compared based on the same planning target volumes (PTVs) with similar dose coverages. Results There was no statistically significant difference in the PTV coverage among three plans (P>0.05). Compared to VMAT and IMRT plans, carbon ion plans reduced the mean doses of eyeballs, mean doses and near-maximum doses of optical nerves of both ipsilateral (t=7.35, 3.79, 4.66, 8.48, 2.52, 2.76, P<0.05) and contralateral eyes (t=3.87, 10.49, 9.16, 4.43, 6.53, 5.12, P<0.05), while the mean dose of brain was decreased from(5.65±3.58) and (5.76±2.09)Gy(RBE) to (0.81±0.90)Gy(RBE) (t=6.76, 17.33,P<0.05). Conclusions Compared to photon VMAT or IMRT, carbon ion could reduce the doses to optical critical organs around tumors. Thus, carbon ion radiotherapy has potential to reduce patients' radiation related side-effects. |
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