| Feng Yanru,Liu Luying,Zhu Yuan.Associations of neutrophil to albumin ratio with acute adverse events and survival in patients with pathological stage Ⅱ/Ⅲ rectal cancer receiving adjuvant chemoradiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2019,39(9):663-667 |
| Associations of neutrophil to albumin ratio with acute adverse events and survival in patients with pathological stage Ⅱ/Ⅲ rectal cancer receiving adjuvant chemoradiotherapy |
| Received:July 05, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2019.09.005 |
| KeyWords:Rectal cancer Neutrophil to albumin ratio Chemoradiotherapy Acute adverse event Survival |
| FundProject:河南省科技计划项目（182102310578） |
| Author Name | Affiliation | E-mail | | Feng Yanru | Department of Radiation Oncology, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Liu Luying | Department of Radiation Oncology, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Zhu Yuan | Department of Radiation Oncology, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China | zhuyuan201412@163.com |
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| Abstract:: |
| Objective To evaluate whether any association exists between peripheral blood cell-based inflammatory biomarkers obtained before adjuvant chemoradiotherapy and adverse events (AEs) and survival of patients with pathological stage Ⅱ/Ⅲ rectal cancer treated by adjuvant chemoradiotherapy. Methods A total of 109 rectal cancer patients were included. The prognostic abilities of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) and neutrophil to albumin ratio (NAR) for overall survival (OS) were calculated by the receiver operating characteristic (ROC) curves. Results NAR was associated with the occurrence of grade ≥ 2 leukopenia (OR=4.442, 95% CI:1.216-16.221, P<0.05). The 5-year OS rates of patients with NAR ≥ 0.055 and patients with NAR<0.055 were 68.2% and 83.9%, respectively (P>0.05). The 5-year disease-free survival (DFS) rates of patients with NAR ≥ 0.055 and patients with NAR<0.055 were 59.1% and 76.8%, respectively (χ2=3.887, P<0.05). Multivariate analysis by Cox proportional-hazards model showed that NAR was significantly associated with OS (HR=3.035, 95% CI:1.021-9.019, P<0.05). Conclusions These results suggest that NAR obtained before adjuvant chemoradiotherapy might serve as an independent biomarker for predicting AEs and prognosis in rectal cancer treated with adjuvant chemoradiotherapy. |
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