| Zhou Cheng,Wu Runye,Zhou Zhaoming,Feng Wei,Xu Yujin,Wang Jin,Zhang Peng,Shi Lei,Chen Yuanyuan,Chen Ming.Normal lung tissue response following hypofractionated radiation based on radiological parameters[J].Chinese Journal of Radiological Medicine and Protection,2019,39(9):641-646 |
| Normal lung tissue response following hypofractionated radiation based on radiological parameters |
| Received:April 26, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2019.09.001 |
| KeyWords:Radiation fractionation Radiation induced lung fibrosis Boltzmann model Radiobiological modeling |
| FundProject:国家自然科学青年科学基金（81703166）；国家重点研发计划课题（2017YFC0113200）；浙江省部共建项目（2014PYA003） |
| Author Name | Affiliation | E-mail | | Zhou Cheng | Zhejiang Key Lab of Radiation Oncology, Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Wu Runye | Department of Radiation Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Zhou Zhaoming | Department of Radiation Medicine, School of Public Health, Southern Medical University, Guangzhou 510515, China | | | Feng Wei | Zhejiang Key Lab of Radiation Oncology, Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Xu Yujin | Zhejiang Key Lab of Radiation Oncology, Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Wang Jin | Zhejiang Key Lab of Radiation Oncology, Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Zhang Peng | Zhejiang Key Lab of Radiation Oncology, Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Shi Lei | Department of Radiology, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Chen Yuanyuan | Zhejiang Key Lab of Radiation Oncology, Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Chen Ming | Zhejiang Key Lab of Radiation Oncology, Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China | chenming@zjcc.org.cn |
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| Abstract:: |
| Objective To study dose-response relationships of fractionated irradiation induced pulmonary fibrosis in mice according to radiological imaging changes of lung. Methods A total of 8-10 week old-female C57BL6 mice were randomized into different groups for whole thoracic irradiation. The prescribed doses were 0, 2.0, 4.0, 6.0, 7.0, 8.5 Gy per fraction in a total of 5 fractions. CT imaging was performed at 24 weeks post irradiation. The averaged lung density and volume changes were obtained by the three-dimensional segmentation algorithm, and further analyzed in Boltzmann regression modeling. Results At the endpoint of 24 weeks, the dose-dependent pulmonary radiological alternations were revealed by coronal view of CT images. Translational analysis of fibrosis-related gene-signatures as well as histological collagen stainings further corroborated the radiological findings. According to Boltzmann modeling, the E50 of radiation-induced lung density changes was found to be (30.80±0.80)Gy (adjusted R2=0.97); whereas the E50 for radiation-induced lung volume reduction was determined as (31.31±7.07)Gy (adjusted R2=0.92). Both outcomes indicated a remarkable enhancement of tolerance to normal lung tissues after exposure with 5-fraction versus single fraction scheme. Conclusions The radiation-induced lung density and volume changes depend not only on total dose, but also the number and dose of fractions. |
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