| Ma Shumei,Liang Zhenzhen,Chen Qiao,Liu Rui,Guo Yutian,Liu Xiaodong.The challenges of precision radiotherapy technology to the traditional theory of radiobiology[J].Chinese Journal of Radiological Medicine and Protection,2019,39(8):563-571 |
| The challenges of precision radiotherapy technology to the traditional theory of radiobiology |
| Received:April 02, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2019.08.002 |
| KeyWords:Precision radiotherapy Radiobiology Linear-quadratic model Biological equivalent dose Radiosensitivity |
| FundProject:National Key Research and Development Program of China (2017YFC0108602); National Natural Science Foundation of China (81573082, 81773363, 81673092) |
| Author Name | Affiliation | E-mail | | Ma Shumei | School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China | | | Liang Zhenzhen | MHC Key Lab of Radiation Biology, School of Public Health, Jilin University, Changchun, Jilin 130021, China | | | Chen Qiao | MHC Key Lab of Radiation Biology, School of Public Health, Jilin University, Changchun, Jilin 130021, China | | | Liu Rui | MHC Key Lab of Radiation Biology, School of Public Health, Jilin University, Changchun, Jilin 130021, China | | | Guo Yutian | Shenzhen Haibo Technology Co., Ltd., Shenzhen 518057, China | | | Liu Xiaodong | School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China | liuxd2002@126.com |
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| Abstract:: |
| With the development of modern computing technology and medical physics, radiotherapy has made great progress. The theoretical basis of radiobiology seems to lag behind the clinical application of radiotherapy, which hampers the further improvement of treatment efficacy and the optimization of treatment modality. In this paper, some emerging challenges of precision radiotherapy technology to the traditional theory of radiobiology, such as radiosensitivity, dose-response curve and survival curve, linear-quadratic model, 4Rs theory, as well as the interaction between cancer and microenvironment, radiation-induced second primary cancers (RISPC), will be discussed. The interplay between precision radiotherapy and traditional radiobiology theories will be addressed with the aim to potentially solve some of the challenging problems. |
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