| Wu Bo,Wang Yong,Zhu Jie,et al.Advance of establishing radioresistant tumor cell lines[J].Chinese Journal of Radiological Medicine and Protection,2018,38(12):956-959 |
| Advance of establishing radioresistant tumor cell lines |
| Received:May 31, 2018 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.12.015 |
| KeyWords:Radiotherapy Radiosensitivity Radioresistance Gradient irradiation |
| FundProject:浙江省公益技术应用研究计划项目（2015C33257） |
| Author Name | Affiliation | | Wu Bo | Department of Radiation Oncology, Taizhou Central Hospital, Affiliated Hospital of Taizhou University, Taizhou 318000, China | | Wang Yong | Department of Radiation Oncology, Taizhou Central Hospital, Affiliated Hospital of Taizhou University, Taizhou 318000, China | | Zhu Jie | Clinical Laboratory, Taizhou Central Hospital, Affiliated Hospital of Taizhou University, Taizhou 318000, China | | Ying Shenpeng | Department of Radiation Oncology, Taizhou Central Hospital, Affiliated Hospital of Taizhou University, Taizhou 318000, China | | Lyu Jiaming | Wenzhou Medical University, Wenzhou 325000, China | | Xiong Huacai | Wenzhou Medical University, Wenzhou 325000, China | | Hu Jie | Department of Radiation Oncology, Taizhou Central Hospital, Affiliated Hospital of Taizhou University, Taizhou 318000, China | | Hu Wei | Department of Radiation Oncology, Taizhou Central Hospital, Affiliated Hospital of Taizhou University, Taizhou 318000, China |
|
| Hits: 3414 |
| Download times: 2125 |
| Abstract:: |
| Radiotherapy is necessary for 70% of malignant tumor patients. Local recurrence and metastasis are primary failure models, where radioresistance is one of important factors. It is critical to establish radioresistant tumor cell lines for understanding the mechanism of radioresistance. According to single radiation, fractioned radiation and the compound radiation method, four representative radiation models are classified:conventional radiation, repeated radiation, gradient radiation and other radiation. These different radiation models have difference in total dose and radiation model as well as the biological characteristics. Superior to other three models, the gradient fractioned irradiation model increase fractioned doses gradually along with the enhancement of radioresistance, which favorably balances the fractioned doses and the time of irradiated cells approaching to exponential growth phase. Clinically relevant radioresistant cell line (CRR) with a genotype in consistent with its parental cells is an important research direction on tumor radioresistance. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
