| Ran Yonghong,Gao Jining,Lu Binghui,et al.Research progresses in the mechanism and treatment of the impaired wound healing of combined radiation-trauma injury[J].Chinese Journal of Radiological Medicine and Protection,2018,38(11):874-880 |
| Research progresses in the mechanism and treatment of the impaired wound healing of combined radiation-trauma injury |
| Received:May 24, 2018 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.11.015 |
| KeyWords:Combined radiation trauma Impaired wound healing Mechanism Therapy |
| FundProject:国家自然科学基金（AWS13J002，AWS14J002，81472913，81741112）；重庆市基础与前沿研究计划项目（cstc2016jcyjA0408） |
| Author Name | Affiliation | E-mail | | Ran Yonghong | State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University, Chongqing 400038, China | | | Gao Jining | State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University, Chongqing 400038, China | | | Lu Binghui | State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University, Chongqing 400038, China | | | He Yingjuan | State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University, Chongqing 400038, China | | | Su Yongping | State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University, Chongqing 400038, China | | | Hao Yuhui | State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University, Chongqing 400038, China | yuhui_hao@126.com |
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| Abstract:: |
| Combined radiation-trauma injury is mainly observed in radiation treatment of cancer and radiation injury with traumatic patients. The prominent problem of combined radiation-trauma injury is delayed or prolonged wound healing. The mechanism of the impaired wound healing is complicated, and the current effective treatment method are limited. This paper reviews the mechanism and treatment of this impaired wound healing, including the cellular depletion, stromal cell dysfunction, aberrant collagen deposition, microvascular damage, as well as the targeted therapies for the impaired wound healing such as stem cell repletion, antioxidant therapy, transforming growth factor beta-1 (TGF-β1) modulation, and implantable biomaterials. This paper is designed to provide a reference for further deep research on the mechanism and treatment of radiation-trauma injury. |
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