| Liu Zhengwen,Shi Yan,Liu Shuming,et al.Study on the influence of 125I seed implantation brachytherapy on QOL of patients with salivary gland malignant tumor[J].Chinese Journal of Radiological Medicine and Protection,2018,38(11):846-850 |
| Study on the influence of 125I seed implantation brachytherapy on QOL of patients with salivary gland malignant tumor |
| Received:May 07, 2018 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.11.009 |
| KeyWords:QOL(Quality of life) Radioactive seeds Brachytherapy Salivary gland malignant tumor |
| FundProject: |
| Author Name | Affiliation | E-mail | | Liu Zhengwen | Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China | | | Shi Yan | Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China | | | Liu Shuming | Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China | | | Wang Haibo | Peking University Clinical Research Institute, Beijing 100191, China | | | Wu Yangfeng | Peking University Clinical Research Institute, Beijing 100191, China | | | Zhang Jianguo | Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China | rszhang@126.com |
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| Abstract:: |
| Objective To evaluate the influence of 125I seed implantation brachytherapy on QOL of patients with salivary gland malignant tumor which couldn't be treated by conventional surgery and its influence factors. Methods 23 patients with malignant salivary gland cancer which couldn't be treated by conventional surgery were selected from Peking University School of Stomatology from 2013 to 2017.The patients were treated by 125I seed implantation brachytherapy.EORTC QLQ-C30(V3.0)as well as QLQ-H&N35 QOL scale (Chinese version) were used for the assessment of post-treatment QOL. Results The survival rate of one year and three years after treatment in 23 patients was 100% and 67%, respectively. The score of the quality of life before and after treatment was 201.48 and 199.48, respectively. The difference was not significant after the test (P>0.05). The level of total QOL and function score were relatively high. Among the influence factors, location of tumor significantly influenced QOL(F=9.127,P<0.05). Other factors still needed research based on larger sample. Conclusions 125I seed implantaion brachytherapy can better protect the head and neck function and maintain the quality of life of patients with salivary gland malignant tumor. |
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