| Li Qian,Yin Yong,Tong Ying,et al.The impact of heartbeat on the left ventricular myocardial and the left anterior descending coronary arterial dosimetry following intensity modulated radiotherapy for left-sided breast cancer[J].Chinese Journal of Radiological Medicine and Protection,2018,38(10):747-750 |
| The impact of heartbeat on the left ventricular myocardial and the left anterior descending coronary arterial dosimetry following intensity modulated radiotherapy for left-sided breast cancer |
| Received:April 10, 2018 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.10.005 |
| KeyWords:Breast carcinoma Intensity modulated radiotherapy Left ventricular myocardial Left anterior descending Dose evaluation |
| FundProject:国家自然科学基金（81301936）；山东省重点研发计划（2018GSF118048） |
| Author Name | Affiliation | E-mail | | Li Qian | School of Nuclear Science and Technology, University of South China, Hengyang 421001, China | | | Yin Yong | Department of Radiation Physics, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China | | | Tong Ying | Department of Radiation Physics, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China | | | Wei Hong | Department of Radiation Physics, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China | | | Cheng Pinjing | School of Nuclear Science and Technology, University of South China, Hengyang 421001, China | | | Gong Guanzhong | Department of Radiation Physics, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China | gongguanzhong@yeah.net |
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| Abstract:: |
| Objective To study the impact of heartbeat on the left ventricular myocardial (mLV) and the left anterior descending (LAD) coronary arterial dosimetry following intensity modulated radiotherapy (IMRT) for left-sided breast carcinoma. Methods A total of 15 female patients who received electrocardiography gated 4D-CT scan in inspiratory breathing-holding were enrolled. According to cardiac cycle, 20 time-phase images were reconstructed from 0 to 95% at 5% interval. Then, the mLV and the LAD were delineated respectively and the IMRT plans of the left breast carcinoma were generated based on 0% phase CT images. The volume and dice similarity coefficient (DSC) of the mLV were calculated, and the variation range of the mLV and the LAD dose-volume indexes were compared among different phases. Results The average rate of DSC variation of mLV was eightfold of volume, which reached to 472.07%,and the average change rate of mLV (Dmean) was up to 41.95%. The difference of the mLV's volume and DSC was statistically significant between the maximum and minimum(t=-6.585, -28.870, P<0.05), as well as the Dmean, V10, V20, V30 and V40(t=-5.260, -4.084, -3.592, -3.273, -2.566, P<0.05). The average change rate of the LAD's Dmean was up to 130.14%. The difference of Dmean, V10, V20, V30 and V40 of LAD was statistically significant between the maximum and minimum(t=-9.758, -8.810, -8.682, -7.853, -6.205,P<0.05). Conclusions The dosimetry impact of heartbeat on mLV and LAD should not be ignored. |
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