| Wu Junlan,Fan Xingwen,Wu Kailiang.The role of regulatory T cells in radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2018,38(9):715-718 |
| The role of regulatory T cells in radiotherapy |
| Received:January 28, 2018 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.09.015 |
| KeyWords:Treg Radiotherapy Tumor immunity |
| FundProject: |
| Author Name | Affiliation | E-mail | | Wu Junlan | Department of Oncology, Shanghai Armed Police Corps Hospital, Shanghai 201103, China | | | Fan Xingwen | Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China | | | Wu Kailiang | Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China | wukailiang@aliyun.com |
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| Abstract:: |
| Regulatory T cells (Treg) play important role in immune homeostasis in physics and hamper the anti-tumor immunity. Depletion of intra-tumor Treg is a critical step to boost the anti-tumor effect in immune therapy. Radiotherapy can induce secretion of TGF-β and IL33 from tumor cells and then increase Treg proliferation and recruitment into tumor through Langerhans cell. Depletion of Treg could increase the local control and abscopal effect of radiotherapy. |
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