| Liu Huilan,Wang Jianlin,Dai Shengbin,et al.Risk factors for radiation esophagitis and pneumonitis in esophageal cancer patients with diabetes or hypertension[J].Chinese Journal of Radiological Medicine and Protection,2018,38(8):584-589 |
| Risk factors for radiation esophagitis and pneumonitis in esophageal cancer patients with diabetes or hypertension |
| Received:January 18, 2018 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.08.005 |
| KeyWords:Diabetes Hypertension Esophageal cancer Radiation esophagitis Radiation pneumonitis |
| FundProject:国家自然科学基金（11705095） |
| Author Name | Affiliation | E-mail | | Liu Huilan | Department of Tumor, Taizhou People's Hospital, Taizhou 225300, China | | | Wang Jianlin | Department of Radiotherapy, Changzhou Second People's Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213001, China | | | Dai Shengbin | Department of Tumor, Taizhou People's Hospital, Taizhou 225300, China | | | Yu Bo | Department of Radiotherapy, Jiangyin People's Hospital, Jiangyin 214400, China | | | Sha Sha | Department of Radiotherapy, Jiangyin People's Hospital, Jiangyin 214400, China | | | Shu Zhongqin | Department of Radiotherapy, Jiangyin People's Hospital, Jiangyin 214400, China | | | Gu Xiaowei | Department of Radiotherapy, Jiangyin People's Hospital, Jiangyin 214400, China | | | Wang Jian | Department of Radiotherapy, Changzhou Second People's Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213001, China | 1627879372@qq.com |
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| Abstract:: |
| Objective To investigate the risk factors for acute radiation esophagitis andpneumonitis after radiation therapy in esophageal cancer (EC) patients with diabetes or hypertension.Methods A total of 373 EC patients receiving three dimensional conformal radiation therapy (3D-CRT) or intensity modulated radiation therapy (IMRT) were included in this study. Among these patients, 42 showed concurrent with diabetes and 99 with hypertension. Radiation esophagitis or pneumonitis in patients with or without diabetes, and with or without hypertension were monitored in the 1-year follow up, respectively.Results The prevalence of grade 1, 2, 3 and 4 radiation esophagitis in diabetes and non-diabetes patients was 40.5%, 38.1%, 14.3%, 4.8% and 66.2%, 27.8%, 2.7%, 1.8%, respectively, while that of the grade 1, 2 and 3 radiation pneumonitis in diabetes and non-diabetes patients was 31.0%, 16.7%, 9.5% and 30.8%, 15.7%,1.2%, respectively. The prevalence of grade 3 or above radiation esophagitis and pneumonitis in patients with diabetes and was significantly higher than those with non-diabetes (χ2=13.573, 12.279, P<0.05). The prevalence of grade 1, 2, 3 and 4 radiation esophagitis in hypertension and non-hypertension patients was 49.5%, 38.4%, 8.1%, 3.0% and 68.2%, 25.5%, 2.6%, 1.8%, respectively, while that of the grade 1, 2 and 3 radiation pneumonitis in hypertension and non-hypertension patients were 30.3%, 18.2%, 5.1% and 31.0%, 15.0%, 1.1%, respectively. The prevalence of grade 3 or above radiation esophagitis and pneumonitis in patients with hypertension was significantly higher than those with non-hypertension (χ2=5.695、5.422, P<0.05). Diabetes is an independent risk factor for grade 3 or above acute radiation esophagitis and pneumonitis.Conclusions Diabetes or hypertension might be risk factors for severe radiation esophagitis and pneumonitis in EC patients receiving radiation therapy. |
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