| Sun Xiaoge,Bao Yingna,Qiu Hui,Shi Jing,Zhang Wei,Yu Zhilong,Xie Conghua.Expressions of PBK and MMP-9 and their effect on concurrent chemoradiotherapy in cervical cancer[J].Chinese Journal of Radiological Medicine and Protection,2018,38(7):529-534 |
| Expressions of PBK and MMP-9 and their effect on concurrent chemoradiotherapy in cervical cancer |
| Received:April 09, 2018 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.07.009 |
| KeyWords:PBK(PDZ binding kinase) Matrix metalloproteinase 9(MMP-9) Concurrent chemoradiotherapy Cervical cancer |
| FundProject:内蒙古自治区自然科学基金项目（2016MS0856） |
| Author Name | Affiliation | E-mail | | Sun Xiaoge | Department of Radiotherapy, Zhongnan Hospital of Wuhan University, Wuhan 430071, China | | | Bao Yingna | Department of Radiotherapy, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China | | | Qiu Hui | Department of Radiotherapy, Zhongnan Hospital of Wuhan University, Wuhan 430071, China | | | Shi Jing | Department of Radiotherapy, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China | | | Zhang Wei | Department of Radiotherapy, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China | | | Yu Zhilong | Department of Radiotherapy, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China | | | Xie Conghua | Department of Radiotherapy, Zhongnan Hospital of Wuhan University, Wuhan 430071, China | chxie_65@whu.edu.cn |
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| Abstract:: |
| Objective To investigate the expression of DNA damage repair factor PDZ binding kinase (PBK) and matrix metalloproteinase 9 (MMP-9) in cervical cancer and the effect on clinical outcomes of concurrent chemoradiotherapy. Methods A total of 65 cervical cancer pathological specimens were collected from January 2014 to July 2016. Immunohistochemistry was used to detect PBK and MMP-9 expression in the specimens.External irrsdeation was treated with intensity-modulated radiation therapy at a dose of 50 Gy/25 F. After 18 times of external irradiation, high-dose rate postoperative treatment was giver at a dose of 30-36 Gy/5-6 F which lasts 3-4 weeks. Weekly chemotherapy with Cisplatin(DDP) begins simultaneously at the beginning of external irradiation. DDP was administered intravenously at a dosage of 40 mg/m2 for 2 to 6 week. All patients were followed-up as routine. The relationship between clinical characteristics and prognosis of patients and the expression of PBK and MMP-9 were analyzed. Results PBK was expressed in 92.3% of tissues and MMP-9 was expressed in 69.2% of tissues. The expression of PBK was positively associated with overall survival (OS) and disease progression-free survival (PFS) of cervical cancer patients (χ2=4.324, 8.068,P<0.05). The expression of MMP-9 was related with PFS (χ2=5.134,P<0.05). Patients with PBK and MMP-9 expression suffered poor OS and PFS (χ2=5.382, 9.364,P<0.05). Conclusions PBK and MMP-9 could be a biomarker to predict the prognosis of cervical cancer. |
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