Tang Yin,Zhang Huojun.Research advances in tumor radiosensitization mediated by topoisomerase inhibitors[J].Chinese Journal of Radiological Medicine and Protection,2018,38(6):466-470
Research advances in tumor radiosensitization mediated by topoisomerase inhibitors
Received:October 16, 2017  
DOI：10.3760/cma.j.issn.0254-5098.2018.06.014
KeyWords:Topoisomerase inhibitors  Radiotherapy  Radiosensitization
FundProject:中国健康促进基金会项目（THC2015001）
Author NameAffiliationE-mail
Tang Yin Department of Radiation Oncology, Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China  
Zhang Huojun Department of Radiation Oncology, Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China chyyzhj@163.com 
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Abstract::
      As anticancer drugs, topoisomerase inhibitors have been widely used in clinical practice, and their radiosensitivity has been gradually recognized. Many topoisomerase inhibitors are currently in pre-clinical and clinical studies. Several studies have shown that some topoisomerase inhibitors may be potential ideal radiosensitizers. However, the physico-chemical properties, toxicity and sensitization effects should be further investigated.
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