| Liu Mengya,Song Jianbo,Gao Jie,Yuan Hui,Wang Yongli,Wang Xingang,Yue Juan,Qin Xiujun,Li Jianguo,Wen Jianhua.The protective effect of hydrogen-rich water on irradiation-induced cognitive dysfunction[J].Chinese Journal of Radiological Medicine and Protection,2018,38(6):414-418,465 |
| The protective effect of hydrogen-rich water on irradiation-induced cognitive dysfunction |
| Received:December 06, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.06.003 |
| KeyWords:Hydrogen-rich water Ionizing radiation Cognitive dysfunction Radiation protection |
| FundProject: |
| Author Name | Affiliation | E-mail | | Liu Mengya | Key Laboratory of Drug Toxicology and Drug for Radiation Injury of Shanxi Province, Institute for Radiation Protection, Taiyuan 030006, China | | | Song Jianbo | Department of Radiotherapy, Shanxi Dayi Hospital, Taiyuan 030032, China | | | Gao Jie | Key Laboratory of Drug Toxicology and Drug for Radiation Injury of Shanxi Province, Institute for Radiation Protection, Taiyuan 030006, China | | | Yuan Hui | Key Laboratory of Drug Toxicology and Drug for Radiation Injury of Shanxi Province, Institute for Radiation Protection, Taiyuan 030006, China | | | Wang Yongli | Key Laboratory of Drug Toxicology and Drug for Radiation Injury of Shanxi Province, Institute for Radiation Protection, Taiyuan 030006, China | | | Wang Xingang | Key Laboratory of Drug Toxicology and Drug for Radiation Injury of Shanxi Province, Institute for Radiation Protection, Taiyuan 030006, China | | | Yue Juan | Key Laboratory of Drug Toxicology and Drug for Radiation Injury of Shanxi Province, Institute for Radiation Protection, Taiyuan 030006, China | | | Qin Xiujun | Key Laboratory of Drug Toxicology and Drug for Radiation Injury of Shanxi Province, Institute for Radiation Protection, Taiyuan 030006, China | | | Li Jianguo | Key Laboratory of Drug Toxicology and Drug for Radiation Injury of Shanxi Province, Institute for Radiation Protection, Taiyuan 030006, China | | | Wen Jianhua | Key Laboratory of Drug Toxicology and Drug for Radiation Injury of Shanxi Province, Institute for Radiation Protection, Taiyuan 030006, China | jianhua570621@163.com |
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| Abstract:: |
| Objective To investigate the protective effect of hydrogen-rich water on rat cognitive dysfunction induced by ionizing radiation. Methods A total of 20 SD rats were randomly divided into four groups with the ramdom number table method:control group (C), hydrogen-rich water group (HRW), irradiation group (IR) and hydrogen-rich water intervention group (HRW+IR), with 5 rats in each group. The spatial memory ability of rats was tested by a morris water maze. The expression of apoptosis-related genes was detected by real-time fluorescence quantitative PCR. The changes of glutathione (GSH), 8-hydroxydeoxy guanosine (8-OHdG) and malondialdehyde (MDA) and SOD were also measured. Results The escape latency (F=6.003, P<0.05) and the swimming distances (F=3.850, P<0.05) of rats in four different groups had statistically significant differences. Compared with the IR group, the escape latency of the HRW+IR group was significantly decreased at 3, 4, 5 d after irradiation (P<0.05), and the swimming distance of this group became much longer (P<0.05). The levels of GSH, 8-OHdG and MDA in these four groups had statistically significant differences (F=6.450, 5.033, 4.113, P<0.05). Compared with IR group, the concentration of GSH was increased (P<0.05), but MDA and 8-OHdG decreased (P<0.05) in the brain tissue of HRW+IR group, and the expressions of caspase-3, caspase-9 and bax genes were reduced (t=2.956,3.087, 5.246, P<0.05), while the expression of bcl-2 gene was enhanced (t=-3.640, P<0.05) in the HRW+IR group. Conclusions Hydrogen-rich water attenuates the oxidative damage of ionizing radiation by neutralizing oxyhydrogen free radicals and thus protects brain from radiation damage. |
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