| Gao Piaoyang,Du Liqing,Liu Qiang.Radioprotective effects of resveratrol and its mechanism[J].Chinese Journal of Radiological Medicine and Protection,2018,38(5):390-394 |
| Radioprotective effects of resveratrol and its mechanism |
| Received:August 30, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.05.013 |
| KeyWords:Resveratrol Ionizing radiation Protection Mechanism |
| FundProject:国家自然科学基金（31670859）；中央高校基本科研业务费专项资金（3332016100） |
| Author Name | Affiliation | E-mail | | Gao Piaoyang | Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China | | | Du Liqing | Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China | | | Liu Qiang | Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China | liuqiang@irm-cams.ac.cn |
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| Abstract:: |
| Resveratrol is a kind of natural active substance, which has strong antioxidant activity and radioprotective effect. A large number of tests have shown that resveratrol can attenuates radiation damage and play an important role in radiation protection, has a good application prospects. This paper reviews the radioprotective effects of resveratrol on the hematopoietic system, the immune system, the nervous system, the respiratory system, and other devices and their mechanisms of action. Including the HO1 signaling pathway, Nrf2 pathway and other antioxidant mechanisms and the activation of Sirt1 regulate the downstream signals, promote TyrRs into the nucleus to play the role of radioprotection. The prospect of application of resveratrol was also prospected. |
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