| Liu Lidong,Yang Zhen,Qiu Xiaoping,et al.The optimal gamma passing rate thresholds of IMRT dosimetric verification in the treatment of esophageal cancer[J].Chinese Journal of Radiological Medicine and Protection,2018,38(4):297-301 |
| The optimal gamma passing rate thresholds of IMRT dosimetric verification in the treatment of esophageal cancer |
| Received:September 26, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.04.010 |
| KeyWords:Intensity-modulated radiotherapy Receiver operating characteristic curve Optimal thresholds Dose volume histogram |
| FundProject:国家自然科学基金（61772555） |
| Author Name | Affiliation | E-mail | | Liu Lidong | College of Nuclear Science and Technology, University of South China, Hengyang 421001, China | | | Yang Zhen | Department of Oncology, Xiangya Hospital to Central South University, Changsha 410008, China | yangzhen@188.com | | Qiu Xiaoping | College of Nuclear Science and Technology, University of South China, Hengyang 421001, China | | | Zhao Yuqian | College of Information Science and Engineering, Central South University, Changsha 410083, China | | | Lei Mingjun | Department of Oncology, Xiangya Hospital to Central South University, Changsha 410008, China | | | Cao Ying | Department of Oncology, Xiangya Hospital to Central South University, Changsha 410008, China | | | Yang Xiaoyu | Department of Oncology, Xiangya Hospital to Central South University, Changsha 410008, China | | | Tang Du | Department of Oncology, Xiangya Hospital to Central South University, Changsha 410008, China | | | Wang Hanyu | College of Nuclear Science and Technology, University of South China, Hengyang 421001, China | | | Zuo Yuhao | College of Nuclear Science and Technology, University of South China, Hengyang 421001, China | |
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| Abstract:: |
| Objective To investigate the optimal gamma passing rate of intensity-modulated radiotherapy (IMRT) dosimetric verification in the treatment of esophageal cancer using a three-dimensional dose verification system EDoseTM. Methods Twenty five esophageal cancer patients treated by 7-field IMRT were retrospectively reviewed. Measured dose distribution were reconstructed on CT image and evaluated by gamma analysis and DVH metrics using the EDoseTM system. Plans with DVH metrics dose difference<5% or with gamma passing > 90% under 3%/3 mm criteria were accepted. The optimal gamma passing rate for criteria of 5%/3 mm, 3%/3 mm, 2%/2 mm were investigated by drawing the receiver operating characteristic(ROC) curves and calculating the Youden Index. The sensitivity and specificity of the these optimal thresholds in the plan verification were also analyzed. Results The optimal thresholds for global gamma indices with 5%/3 mm, 3%/3 mm, 2%/2 mm were 98.66%, 94.84%, 78.56%, respectively. In the 90% common threshold, The sensitivity and specificity for common 90% threshold and optimal threshold under 3%/3 mm criteria were 0.17 vs. 0.85 and t 0.84 vs. 0.27, respectively. The sensitivity and specificity were 0.89, 0.65 and 0.23, 0.47 for optimal thresholds under 5%/3 mm and 2%/2 mm criteria, respectively. Conclusions The sensitivity of optimal threshold gamma passing rate improved significantly compared with the common threshold (90%) at 3%/3 mm criteria.,The sensitivity and the specificity were more balanced at the 2%/2 mm criteria compared with those at 3%/3 mm criteria. |
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