| Qin Shangbin,Gao Xianshu,Li Hongzhen,Li Xiaoying,Qi Xin,Ren Xueying.Phase I study of moderately hypo-fractionated intensity modulated radiotherapy after prostatectomy[J].Chinese Journal of Radiological Medicine and Protection,2018,38(3):201-204 |
| Phase I study of moderately hypo-fractionated intensity modulated radiotherapy after prostatectomy |
| Received:January 19, 2018 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.03.008 |
| KeyWords:Prostatectom cancer Moderately hypo-fractionated radiotherapy Postoperative radiotherapy |
| FundProject:国家自然科学基金青年基金（11405235） |
| Author Name | Affiliation | E-mail | | Qin Shangbin | Department of Radiation Oncology, Prostate Cancer Radiotherapy Center, Peking University First Hospital, Beijing 100034, China | | | Gao Xianshu | Department of Radiation Oncology, Prostate Cancer Radiotherapy Center, Peking University First Hospital, Beijing 100034, China | doctorgaoxs@126.com | | Li Hongzhen | Department of Radiation Oncology, Prostate Cancer Radiotherapy Center, Peking University First Hospital, Beijing 100034, China | | | Li Xiaoying | Department of Radiation Oncology, Prostate Cancer Radiotherapy Center, Peking University First Hospital, Beijing 100034, China | | | Qi Xin | Department of Radiation Oncology, Prostate Cancer Radiotherapy Center, Peking University First Hospital, Beijing 100034, China | | | Ren Xueying | Department of Radiation Oncology, Prostate Cancer Radiotherapy Center, Peking University First Hospital, Beijing 100034, China | |
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| Abstract:: |
| Objective To assess the acute toxicity of a hypo-fractionated regimen of intensity-modulated radiotherapy to the prostatic bed after prostatectomy. Methods From February to August 2017, twenty cases with prostate adenocarcinoma after prostatectomy were recruited. The prescribed dose to the whole pelvis and the prostatic bed was 45 Gy delivered in 1.8 Gy per fraction and 62.75 Gy delivered in 2.51 Gy per fraction, respectively. Acute toxicity was recorded and graded according to Radiation Therapy Oncology Group (RTOG) criteria and Common Terminology Criteria for Adverse Events (CTCAE) 4.0. Results The median follow-up was 7.5 months. Grade 2 acute genitourinary and gastrointestinal toxicity was observed respectively in two cases (10%) and one (5%), respectively. Two cases(10%) complained of grade 2 urinary incontinence during radiation therapy, but recovered to grade 0 or grade 1 after the first month of follow-up. Conclusions After prostatectomy, moderately hypo-fractionated radiotherapy (2.51 Gy×25) compared with conventional fractionated radiotherapy previously reported did not increase the risk of acute toxicity. The incidence of urinary incontinence did not increase during short-term of follow-up. |
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