Gao Yan,Zhong Heli,Zhou Yayan,Li Zhuangling,Li Weihao,Liu Yajie.Cardiac dosimetric evaluation of tangential VMAT technique in patients with left breast cancer after breast-conserving surgery, including internal mammary lymph node irradiation[J].Chinese Journal of Radiological Medicine and Protection,2018,38(3):180-186 |
Cardiac dosimetric evaluation of tangential VMAT technique in patients with left breast cancer after breast-conserving surgery, including internal mammary lymph node irradiation |
Received:October 18, 2017 |
DOI:10.3760/cma.j.issn.0254-5098.2018.03.004 |
KeyWords:Breast cancer Cardiac toxicity Volumetric modulated arc therapy Intensity-modulated radiotherapy |
FundProject:Shenzhen Science and Technology Research and Development Fund (JCYJ20150403101028189) |
Author Name | Affiliation | E-mail | Gao Yan | Department of Radiation Oncology, Shenzhen People's Hospital Second Clinical Medical College of Jinan University, Shenzhen 518020, China | | Zhong Heli | Department of Radiation Oncology, Shenzhen People's Hospital Second Clinical Medical College of Jinan University, Shenzhen 518020, China | | Zhou Yayan | Department of Radiation Oncology, Shenzhen People's Hospital Second Clinical Medical College of Jinan University, Shenzhen 518020, China | | Li Zhuangling | Department of Radiation Oncology, Shenzhen People's Hospital Second Clinical Medical College of Jinan University, Shenzhen 518020, China | | Li Weihao | Department of Radiation Oncology, Shenzhen People's Hospital Second Clinical Medical College of Jinan University, Shenzhen 518020, China | | Liu Yajie | Department of Radiation Oncology, Peking University Shenzhen Hospital, Shenzhen 518036, China | Anthea1966@163.com |
|
Hits: 3467 |
Download times: 2021 |
Abstract:: |
Objective To investigate the potential heart sparing effects of tangential volumetric modulated arc therapy (T-VMAT) by comparing its dosimetric properties with conventional wedged tangential fields (W-TF) technique and 6-field intensity-modulated radiotherapy (6F-IMRT) in the loco-regional radiotherapy of left breast cancer after conserving surgery, including internal mammary nodal irradiation. Methods Fifteen patients with left breast cancer were enrolled in this study. Three plans were generated for each patient:W-TF, 6F-IMRT and T-VMAT with two arc segments of 50°. The prescription dose to planning tumor volume (PTV) was 50 Gy in 25 fractions. Dose-volume parameters and indices of conformity were calculated and compared for the PTV and organs at risk (OAR). Results Compared with W-TF, T-VMAT not only significantly decreased Dmax, Dmean and the high dose areas (above 10 Gy) of the heart and left anterior descending branch (LAD) (P<0.05), but also had the trend of sparing the V5 Gy although there was statistically significant difference (P>0.05). T-VMAT also significantly decreased Dmean, V5 Gy, V10 Gy and V20 Gy of the heart, as well as the Dmean, V5 Gy and V10 Gy of LAD (P<0.05), compared to 6F-IMRT. Furthermore, T-VMAT did not result in higher V20 Gy of ipsilateral lung and higher V5 Gy of contralateral breast compared with W-TF (P>0.05). T-VMAT achieved distinctly better target coverage and conformity, meanwhile obviously lowered hot volume of V110 compared to W-TF (P<0.05). Conclusions T-VMAT not only significantly decreased the high dose areas, but also had the trend of sparing the low dose area for the heat and LAD. Moreover, there was no significant difference for V20 Gy of ipsilateral lung and V5 Gy of contralateral breast between T-VMAT and W-TF. |
HTML View Full Text View/Add Comment Download reader |
Close |
|
|
|