| Xie Tieming,Kong Yue,Shi Lei,Du Fenglei,Huang Shuang,Hua Yonghong,Hu Qiaoying,Jin Ting,Chen Xiaozhong,Chen Yuanyuan.Analysis of memory function and MRI changes in nasopharyngeal carcinoma patients after radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2018,38(2):105-109 |
| Analysis of memory function and MRI changes in nasopharyngeal carcinoma patients after radiotherapy |
| Received:June 01, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.02.005 |
| KeyWords:Nasopharyngeal carcinoma Radiation-induced injury Hippocampus Temporal lobe MRI |
| FundProject: |
| Author Name | Affiliation | E-mail | | Xie Tieming | Department of Radiology, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Kong Yue | Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Shi Lei | Department of Radiology, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Du Fenglei | Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Huang Shuang | Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Hua Yonghong | Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Hu Qiaoying | Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Jin Ting | Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Chen Xiaozhong | Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Chen Yuanyuan | Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China | chenyy@zjcc.org.cn |
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| Abstract:: |
| Objective To analyse the memory function and MRI changes in local-advanced nasopharyngeal carcinoma patients before-and after-radiation.Methods Clinical data, dosimetric data, digital span score and MRI of 14 cases with nasopharyngeal carcinom treated in Zhejiang Cancer Hospital from November 2015 to August 2016 were retrospectively analysed. There were 1 case at T2 stage, 7 cases at T3 and 6 at T4. They received IMRT or TOMO therapy concurrent with 2 cycles Nedaplatin after 2-3 cycles PF/TP induction chemotherapy. Results The IMRT dosimetric data of 9 cases were available. For hippocampus and temporal lobe,the mean volume was (15.17±2.17) and (95.07±12.26) cm3, respectively, while the mean dose was (1 154.06±771.63) and (1 306.61±603.69) Gy,and the max dose (3 797.61±1 450.98) and (5 394.17±982.28) Gy, respectively. The equivalent uniform dose (EUD) was (2 233.28±872.73) Gy for hippocampus and (3 113.11±603.69) Gy for temporal lobe. 10 patients received digit span score before-and 3 months after-radiotherapy. The mean score of forward digit span was 8.8±1.8 before radiation and 8.1±1.59 at 3 months after radiation(P>0.05), while that of backward digit span decreased from 6.2±1.04 before radiation to 5.3±2.36 at 3 months after radiation (t=3.25, P>0.05). 9 patients' MRI were available. Volume reduction of temporal lobe was observed(t=4.57, P<0.01)by voxel-based morphometry (VBM).Conclusions Radiation-induced injury to hippocampus and temporal lobe is inevitable in local-advanced nasopharyngeal carcinoma patients. There might be some connection between memory loss and temporal lobe volume atrophy after radiotherapy. Enrollment of larger sample analysis is expected. |
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