| Wang Ping,Su Yinping,Gao Yu,et al.Follow-up of radiosensitive tissues in children with congenital heart disease treated by interventional operation[J].Chinese Journal of Radiological Medicine and Protection,2018,38(1):37-42 |
| Follow-up of radiosensitive tissues in children with congenital heart disease treated by interventional operation |
| Received:October 10, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.01.008 |
| KeyWords:Interventional therapy Congenital heart disease Thyroid Peripheral blood Chromosomal aberrations Children |
| FundProject:国家重点临床专科建设项目（2011-17）；河南省重点科技攻关项目（142102310086） |
| Author Name | Affiliation | E-mail | | Wang Ping | Department of Toxicology, Henan Institute of Occupational Medicine, Zhengzhou 450052, China | | | Su Yinping | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Gao Yu | College of Public Health, Zhengzhou University, Zhengzhou 450001, China | | | Han Lin | Department of Toxicology, Henan Institute of Occupational Medicine, Zhengzhou 450052, China | | | Li Jie | Department of Toxicology, Henan Institute of Occupational Medicine, Zhengzhou 450052, China | | | Fu Yinghua | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Zhao Fengling | Department of Toxicology, Henan Institute of Occupational Medicine, Zhengzhou 450052, China | | | Lyu Yumin | Department of Toxicology, Henan Institute of Occupational Medicine, Zhengzhou 450052, China | | | Sun Quanfu | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | sunquanfu@nirp.chinacdc.cn |
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| Abstract:: |
| Objective To understand effects of the interventional operation on thyroid, peripheral blood indexes and chromosomal aberrations (CA) of peripheral lymphocyte of children with congenital heart disease (CHD). Methods Follow-up studies were conducted in 70 child patients undergoing cardiac catheterization and 23 with open heart surgery as control from 2010 to 2013. Postoperative follow-up examinations included thyroid ultrasound, blood routine indexes and analyses of CAs. Results Difference in thyroid ultrasound abnormality rate was not statistically significant between children with cardiac catheterization and control group (40.0% vs.43.5%, P>0.05). There was no significant difference in white blood cell (WBC) count between interventional group and control group (P>0.05). The effects of disease type and operation time on thyroid ultrasound and WBC count were not observed (P>0.05). The frequency of chromosome aberrations, including acentric fragment, dicentrics and translocation in interventional group[(0.76±0.07)%], was higher than in control group[(0.25±0.07)%, (Z=-3.631, P < 0.05], and the rates of acentric fragment and translocation were also higher in interventional group (Z=-2.531, -2.397, P < 0.05). Conclusions Effect of intervention therapy on thyroid structure and WBC count in children with CHD was not observed, but the genotoxic effects remain in children with cardiac catheterization. |
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