| Huang Ying,Zhuo Weihai,Liu Haikuan,Zheng Xiangpeng,Qiu Jianjian.Estimated radiation dose and breast cancer incidence risk of contra-lateral breast for patients with unilateral breast cancer[J].Chinese Journal of Radiological Medicine and Protection,2017,37(12):924-927 |
| Estimated radiation dose and breast cancer incidence risk of contra-lateral breast for patients with unilateral breast cancer |
| Received:May 23, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.12.009 |
| KeyWords:Radiotherapy Breast cancer Contra-lateral breast Radiation dose Lifetime attribute risk |
| FundProject:上海市卫生和计划生育委员会科研课题（219） |
| Author Name | Affiliation | E-mail | | Huang Ying | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | | Zhuo Weihai | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | | Liu Haikuan | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | | Zheng Xiangpeng | Department of Radiotherapy, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China | | | Qiu Jianjian | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | ninian-qiu@126.com |
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| Abstract:: |
| Objective To analyze the radiation dose to contra-lateral breasts and estimate the incidence risk of contra-lateral breast cancer for women undergone unilateral breast cancer radiotherapy. Methods The radiation doses of contra-lateral breasts for 49 patients were counted and analyzed in a hospital, and the risk of contra-lateral breast cancer in different age groups that induced by radiotherapy was estimated based on BEIR Ⅶ model combined with the Chinese lifetime table. Results The prescribed doses for the patients were all 50 Gy. The mean dose to contra-lateral breasts ranged from 0.14 Gy to 3.59 Gy, with an average of (1.21±0.89) Gy, and the maximum point dose varied from 0.98 Gy to 45.27 Gy, with the average of (17.42±13.20) Gy. Both the maximum point dose and the mean dose obviously varied among the patients, and their correlation was significant (R=0.527,P=0.000). Furthermore, no significant differences of the mean dose was found among the ages (P>0.05). The lifetime attribute risks of contra-lateral breast cancer were estimated to be 2 449, 1 857, 994, 446, 173 and 55 for per 100 thousand women corresponding to the ages of 35, 40, 50, 60, 70 and 80, respectively. Conclusions In the radiotherapy for unilateral breast cancer, the dose delivered to the contra-lateral breast is about 1 Gy order of magnitude, the risk of contra-lateral breast cancer cannot be ignored for young women. Therefore, the irradiation dose of contra-lateral breasts should be controlled as less as possible in planning the treatment. |
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