| Yan Weiliang,Huo Xiaodong,Huo Bin,et al.Efficacy analysis of chemotherapy in combination with 125I seed implantation for treatment of inoperational pancoast tumor[J].Chinese Journal of Radiological Medicine and Protection,2017,37(12):911-914 |
| Efficacy analysis of chemotherapy in combination with 125I seed implantation for treatment of inoperational pancoast tumor |
| Received:May 09, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.12.006 |
| KeyWords:125I Brachytherapy Pancoast tumor Efficacy |
| FundProject:天津市自然科学基金（15JCYBJC28400） |
| Author Name | Affiliation | E-mail | | Yan Weiliang | Department of Thoracic Surgery, Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Huo Xiaodong | Department of Oncology, Second Hospital of Tianjin Medical University, Tianjin 300211, China | xiaodonghuo@126.com | | Huo Bin | Department of Oncology, Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Wang Haitao | Department of Oncology, Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Zheng Guangjun | Department of Thoracic Surgery, Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Shi Shuyuan | Department of Thoracic Surgery, Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Feng Zhen | Department of Thoracic Surgery, Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Chai Shude | Department of Thoracic Surgery, Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Wang Junjie | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | |
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| Abstract:: |
| Objective To explore the therapeutic effect of radioactive 125I seeds combined with chemotherapy on the treatment of inoperative pancoast tumor by CT-guided percutaneous implantation of treatment planning system (TPS). Methods From December 2002 to December 2010, 36 patients with pancoast tumor were confirmed by imaging and pathology. Among them, 26 cases suffered from squamous cell carcinoma and 10 cases with adenocarcinoma. At 1 week after radioactive 125I implantation, chemotherapy was administered as intravenous 1 000 mg/m2 gemcitabine at 1 and 8 d and intravenous cisplatin 75 mg/m2 at 1 d for 4 consecutive cycles. The prescribed dose (PD) was 120 Gy, and the median activity of the seeds was 0.7 mCi(2.59×107 Bq)with the range of 0.68-0.82 mCi (2.52×107-3.03×107 Bq). The patients were followed-up and the median follow-up time was 48 months. The survival rate was observed. Results The mPD of the target tumor was (118.7±7.2) Gy, D90 (126±4.7) Gy, D90> mPD. The rate of CR (11 cases) was 63.6%, and the effective rate (CR+PR) was 83.4%. The follow-up last till December 1st, 2016. 1-,3-and 5-year local control rates were 92%, 83%, and 67%, respectively. 1-,3-and 5-year cumulative survival rate were 84.1%, 56.7%, and 36.8%, respectively. Median survival was 38 months. Conclusions Chemotherapy combined with tissue radioactive 125I seed implantation is a minimally invasive and effective method for the treatment of pancoast tumor. |
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