| Peng Wei,Chen Jin,Wei Wei,et al.Serum KL-6 predicts the risk of pneumonitis induction after radiotherapy of human lung cancer[J].Chinese Journal of Radiological Medicine and Protection,2017,37(12):891-895 |
| Serum KL-6 predicts the risk of pneumonitis induction after radiotherapy of human lung cancer |
| Received:June 03, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.12.002 |
| KeyWords:Lung cancer KL-6 Radiation pneumonitis(RP) Radiation therapy |
| FundProject:国家临床重点专科建设项目 |
| Author Name | Affiliation | E-mail | | Peng Wei | Department of Clinical Laboratory, Fujian Tumor Hospital, Fujian Medical University, Fuzhou 350014, China | | | Chen Jin | Department of Clinical Laboratory, Fujian Tumor Hospital, Fujian Medical University, Fuzhou 350014, China | | | Wei Wei | Department of Radiation Oncology, Fujian Tumor Hospital, Fujian Medical University, Fuzhou 350014, China | | | Cui Zhaolei | Department of Clinical Laboratory, Fujian Tumor Hospital, Fujian Medical University, Fuzhou 350014, China | | | Su Guangjian | Department of Clinical Laboratory, Fujian Tumor Hospital, Fujian Medical University, Fuzhou 350014, China | | | Chen Yansong | Department of Clinical Laboratory, Fujian Tumor Hospital, Fujian Medical University, Fuzhou 350014, China | | | Chen Yan | Department of Clinical Laboratory, Fujian Tumor Hospital, Fujian Medical University, Fuzhou 350014, China | yanc99@sina.com |
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| Abstract:: |
| Objective To explore the irradiation-increased krebs von den lungen-6 (KL-6) in predicting radiation pneumonitis (RP) after lung cancer radiotherapy. Methods A total of 87 hospitalized patients with Ⅰ-Ⅲ stages of lung cancer from June 2015 to December 2015 were followed up, and their clinicopathological data and serum KL-6, transforming growth factor-beta 1 (TGF-β1)and lactate dehydrogenase (LDH)before and 3 months after radiotherapy were analyzed to determine their role in predicting RP induction in lung cancer. Results Among the 87 lung cancer patients based on clinical symptoms and chest CT, 13 patients were diagnosed with ≥ 2 grape RP. Before radiotherapy, the average levels of serum KL-6 were (247±105.44) U/ml in 13 patients with ≥ 2 grape RP and (209±71.09) U/ml in 74 cases 0/1 grape RP, respectively. Within 3 months after radiotherapy, the highest level of KL-6 approached to (456±202.84) and (222±80.42) U/ml with increase ratios of 2.01±1.04 and 1.13±0.60 in the ≥ 2 grape RP and 0/1 grape RP, respectively. The difference of KL-6 levels between these two groups was significant (t=2.901,P<0.005). While the levels of TGF-β1 and LDH did not change. ROC analysis showed that the sensitivity of the ratio of serum KL-6 increased after radiotherapy was 0.923% and the specificity was 0.851% at 1.435 as the critical value. Furthermore, the multi-variate logistic regression analysis showed that the ratio of KL-6 increased as an independent risk factor of ≥ 2 grade RP in lung cancer (OR=12.886, 95%CI=3.372-49.247, P=0.002). Conclusions The increased ratio (≥ 1.435) of KL-6 is closely correlated with the ≥ 2 grape RP in lung cancer, which could be used as a predictor of ≥ 2 grape RP in lung cancer. |
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