| Lin Zhongwu,Wang Qi,Wang Zhidong.Overview of current situation and future development of radiation biodosimetry study[J].Chinese Journal of Radiological Medicine and Protection,2017,37(10):799-804 |
| Overview of current situation and future development of radiation biodosimetry study |
| Received:June 28, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.10.015 |
| KeyWords:Radiation biodosimeter Chromosome aberration γ-H2AX Molecular biomarker |
| FundProject:军队医学科技青年培育项目（15QNP089）；全军后勤科研重大专项（AWS14C014） |
|
| Hits: 3678 |
| Download times: 2361 |
| Abstract:: |
| Radiation biodosimetry is an important part of radiation medicine. Some new discoveries and progresses have been made in radiation biodosimetry studies in recent years. Cytogenetic method represented by chromosome aberration analysis as the golden standard of radiation biodosimeter is being transformed to automate analysis, and a number of international, regional and national laboratory networks of radiation biodosimetry are being established. As a widely acceptable molecular marker of DNA damage, γ-H2AX has made rapid progress in radiation dose estimation. Based on the expressions of protein and genes, further advancements have been made in the studies of metabolites and miRNAs. At the same time, with the development of proteomics technology, there are some breakthroughs in the study of using molecular expression profiling to evaluate radiation dose. The research progresses of radiation biodosimetry is reviewed in this paper. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
