| Sun Wen,Niu Hongxin,Zhang Xikun,Wang Bin,Yang Huangang,Zhong Feng,Sun Lin,Wang Jian,Hao Liang,Song Wentao.Clinical analysis of 10 cases of advanced esophageal carcinoma treated with radioactive gastric tube of 125I seeds[J].Chinese Journal of Radiological Medicine and Protection,2017,37(10):752-757 |
| Clinical analysis of 10 cases of advanced esophageal carcinoma treated with radioactive gastric tube of 125I seeds |
| Received:April 06, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.10.006 |
| KeyWords:Esophageal carcinoma 125I seed Gastric tube Intracavitary brachytherapy |
| FundProject:山东省科技发展计划项目（2014GSF118182） |
| Author Name | Affiliation | E-mail | | Sun Wen | School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250200, China | | | Niu Hongxin | Department of Minimally Invasive Surgery, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan 250031, China | sdblache@126.com | | Zhang Xikun | Department of Minimally Invasive Surgery, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan 250031, China | | | Wang Bin | Department of Minimally Invasive Surgery, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan 250031, China | | | Yang Huangang | Department of Minimally Invasive Surgery, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan 250031, China | | | Zhong Feng | Department of Minimally Invasive Surgery, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan 250031, China | | | Sun Lin | Department of Minimally Invasive Surgery, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan 250031, China | | | Wang Jian | Department of Minimally Invasive Surgery, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan 250031, China | | | Hao Liang | Department of Minimally Invasive Surgery, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan 250031, China | | | Song Wentao | Department of Minimally Invasive Surgery, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan 250031, China | |
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| Abstract:: |
| Objective To explore the feasibility, safety and preliminary efficacy of radioactive gastric tube of 125I seeds in the treatment of advanced esophageal carcinoma.Method For 10 cases with advanced esophageal carcinoma, the tumor target area was outlined in the TPS system according to preoperative CT images. Prescription dose was 60 Gy with 125I seed radioactivity of 2.22×107 Bq. Accordingly, the 125I seeds number and the appropriate gastric tube was decided. Then, depending on the location of the tumor and certain rules, 125I seeds were fixed in the tube wall to make the radioactive 125I seeds gastric tube. Under the C- arm X-ray fluoroscopy, the radioactive 125I seeds gastric tubes were placed into esophageal carcinoma site of the patients.Results The radioactive 125I seeds gastric tubes of 10 patients were successfully placed, without esophageal perforation, bleeding complications and so on. In one month after operation, all patients with dysphagia's Stooler classification score were 2-3 level,of which one case died of other basic diseases in three months after operation, and six cases achieved 0-1 level while the other three cases achieved 1-2 level in four months after operation. There were no cases of postoperative chest pain, bleeding, pneumonia and other related complications.Conclusions The radioactive 125I seeds gastric tube could not only help to solve nutrition problems, but also the intracavitary brachytherapy inhibit the growth of tumor, which is safe and feasible in clinical use. It can be used as a palliative treatment for patients with advanced esophageal carcinoma. |
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