| Zhao Xue,Yang Yunshuang,Zhang Rong,Kuang Zhenkun,Du Lei,Shi Pengzhan,Yu Lei.The preventive and therapeutic effect of Bushen Jiedu prescription on radiation induced sex hormone disorder[J].Chinese Journal of Radiological Medicine and Protection,2017,37(8):565-569 |
| The preventive and therapeutic effect of Bushen Jiedu prescription on radiation induced sex hormone disorder |
| Received:March 23, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.08.001 |
| KeyWords:Ionizing radiation Bushen Jiedu prescription Sex hormone |
| FundProject:国家自然科学基金（81673873） |
| Author Name | Affiliation | E-mail | | Zhao Xue | PLA Rocket Force General Hospital Training Base, Jinzhou Medical University, Jinzhou 121000, China | | | Yang Yunshuang | Department of TCM and Rehabilitation Medicine, PLA Rocket Force General Hospital, Beijing 100088, China | | | Zhang Rong | Department of Medical Affairs, PLA Rocket Force General Hospital, Beijing 100088, China | zhangrongyisheng@sina.com | | Kuang Zhenkun | PLA Rocket Force General Hospital Training Base, Jinzhou Medical University, Jinzhou 121000, China | | | Du Lei | Department of TCM and Rehabilitation Medicine, PLA Rocket Force General Hospital, Beijing 100088, China | | | Shi Pengzhan | Department of TCM and Rehabilitation Medicine, PLA Rocket Force General Hospital, Beijing 100088, China | | | Yu Lei | PLA Rocket Force General Hospital Training Base, Jinzhou Medical University, Jinzhou 121000, China | |
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| Abstract:: |
| Objective To investigate the preventive and therapeutic effect of Bushen Jiedu prescription on ionizing radiation induced sex hormone disorder. Methods Totally 72 adult rats with half male and half female were randomly divided into 6 groups, including control group, radiation group, Bushen Jiedu prescription group with male and female, with 12 rats in each group. After adaptive breeding for 2 d, the rats of Bushen Jiedu prescription group were given 0.2 ml water soluble granules of Bushen Jiedu prescription (1.38 g/ml) by gavage once a day for 10 days. At 11 d, the rats were irradiated by 5 Gy of 60Co γ-rays. 24 h after radiation, 6 rats in each group were executed to measure the level of sex hormone. The other rats were further gavaged with Bushen Jiedu prescription or its control once a day for 14 d, then were executed for sex hormone testing. Results At 1 d after radiation, the estrogen (E2) of female of Bushen Jiedu prescription group was significantly higher than that of radiation group (t=2.686, P<0.01). Compared with control group, the levels of follicule-stimulating hormone (FSH) (t=4.305, 4.642, P<0.01) of male and female, the levels of luteinizing hormone (LH) of male radiation group, and Bushen Jiedu prescription group were increased (t=4.537, 2.336, P<0.01). At 14 d after radiation, the levels of testosterone and luteinizing hormone in male rats of radiation group was higher than those in control group (t=-3.730, 2.963, P<0.05), and the levels of E2 and progesterone of female was lower than those in control group (t=-5.424, -3.178, -2.690, -3.215, P<0.01). Conclusions Ionizing radiation can induced sex hormone disorder, and Bushen Jiedu prescription can effectively inhibit this alteration, which indicates that Bushen Jiedu prescription is an ideal radiation protectant. |
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