| Hou Dingkun,Huo Bin,Huo Xiaodong,Wang Hao,Wang Lili,Zang Li,Wang Jinhuan,Chai Shude,Wang Haitao.Efficacy and safety of stents loaded with 125Ⅰ seeds for patients with advanced esophageal cancer: a meta-analysis[J].Chinese Journal of Radiological Medicine and Protection,2017,37(7):550-556 |
| Efficacy and safety of stents loaded with 125Ⅰ seeds for patients with advanced esophageal cancer: a meta-analysis |
| Received:January 20, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.07.015 |
| KeyWords:Esophagus cancer 125Ⅰ seeds Efficacy-based Safety Meta analysis |
| FundProject:国家肿瘤临床医学研究中心个体化医学平台建设项目（13ZCZCSY20300）；国家自然科学基金项目（81572543） |
| Author Name | Affiliation | E-mail | | Hou Dingkun | Department of Oncology, Second Affiliated Hospital of Tianjin Medical University, Tianjin 300211, China | | | Huo Bin | Department of Oncology, Second Affiliated Hospital of Tianjin Medical University, Tianjin 300211, China | | | Huo Xiaodong | Department of Oncology, Second Affiliated Hospital of Tianjin Medical University, Tianjin 300211, China | | | Wang Hao | Department of Oncology, Second Affiliated Hospital of Tianjin Medical University, Tianjin 300211, China | | | Wang Lili | Department of Oncology, Second Affiliated Hospital of Tianjin Medical University, Tianjin 300211, China | | | Zang Li | Department of Oncology, Second Affiliated Hospital of Tianjin Medical University, Tianjin 300211, China | | | Wang Jinhuan | Department of Oncology, Second Affiliated Hospital of Tianjin Medical University, Tianjin 300211, China | | | Chai Shude | Department of Thoracic Surgery, Second Affiliated Hospital of Tianjin Medical University, Tianjin 300211, China | | | Wang Haitao | Department of Oncology, Second Affiliated Hospital of Tianjin Medical University, Tianjin 300211, China | peterrock2000@126.com |
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| Abstract:: |
| Objective To evaluate the clinical effectiveness and safety of stents loaded with 125Ⅰ seeds compared to conventional stents. Methods Literatures were searched in PubMed, EMbase, Cochrane Library, CBM, CNKI, Wanfang Data and other electronic databases from inception to November 2016. Two reviewers independently screened the literature according to the inclusion and exclusion criteria, extracted data and assessed quality of the included studies independently. Meta-analyses were performed using RevMan 5.3. Results A total of five RCTs and 14 CCTs involving 1 211 patients were included. The mean survival time of the 125Ⅰ stent group was significantly higher than that of the control group[mean difference=4.11, 95% CI (2.16-6.07)P <0.001]. The incidence of restenosis after 3:The available data showed that the incidence of re-staging of 125Ⅰ stent in the treatment group was lower than that of the normal stent group[RR=0.23, 95%CI(0.12-0.62), P=0.002]. Postoperative bleeding[RR=0.80, 95%CI (0.52-1.23), P=0.30]; Postoperative pain[RR=1.06,95%CI(90.88-1.27),P=0.55]; postoperative stent shift [RR=0.53,95%CI(0.27-1.05), P=0.07]. The difference of incidence of complications was not statistically significant.There was no difference in the incidence of complications between the two groups. Conclusions The available data suggest that 125Ⅰ stent is superior to common stent in the treatment of advanced esophageal cancer. There are no differences found in the incidence of complications between 125Ⅰ stent and conventional stent. However, due to the limited quality of the included studies,more high-quality and multicenter-based studies are needed to verify the above conclusion. |
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