| Wang Lei,Huo Bin,Wang Jinhuan,Wang Lili,Zang Li,Cao Qiang,Huo Xiaodong,Wang Haitao,Chai Shude,Wang Junjie.An analysis of the effect of midazolam conscious sedation therapy in patients with 125Ⅰ seed implantation[J].Chinese Journal of Radiological Medicine and Protection,2017,37(7):518-521,532 |
| An analysis of the effect of midazolam conscious sedation therapy in patients with 125Ⅰ seed implantation |
| Received:April 06, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.07.009 |
| KeyWords:CT guided 125Ⅰ seeds Brachytherapy Midazolam Sedation |
| FundProject:国家自然科学基金项目（81572543）；天津市卫生行业重点攻关项目（14KG141） |
| Author Name | Affiliation | E-mail | | Wang Lei | Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Huo Bin | Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Wang Jinhuan | Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Wang Lili | Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Zang Li | Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Cao Qiang | Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Huo Xiaodong | Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Wang Haitao | Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China | peterrock2000@126.com | | Chai Shude | Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Wang Junjie | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | |
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| Abstract:: |
| Objective To investigate the clinical effect of midazolam in CT-guided 125Ⅰ seed implantation. Methods Totally 86 patients who underwent CT-guided radioactive 125Ⅰ seed implantation were collected from December 2015 to February 2017 in the Second Hospital of Tianjin Medical University and randomly divided into two groups: the test group and the control group. The test group was given intravenous infusion of midazolam and local anesthesia of lidocaine while the control group were given the same amount of saline and lidocaine. The changes of heart rate (HR), mean arterial pressure (MAP), respiration (RR) and oxygen saturation (SpO2) were observed and compared between the two groups at 15 min before the midazolam(T0), 15 min after the midazolam(T1),15 min after lidocaine local anesthesia(T2), the moments the lesion was punctured (T3), and after implantation of the seeds (T4) and the end of the operation(T5), respectively. In addition, the body reaction, operation time, the amount of lidocaine, the effect of analgesic and adverse reactions were also observed. Results The levels of HR, MAP,RR and SpO2 in test group were significantly lower than those in control group(t=38.9, 31.0, 14.1, 2.4, P<0.05), but there was no significant difference at T1, T2, T3, T4 and T5(P>0.05). In control group, HR, MAP and RR were significantly higher than those before operation (t=-23.6, -18.0, -9.5, P<0.05). The difference of HR, MAP,RR and SpO2 among T1, T2, T3, T4 and T5 was statistically significant (F=997.3, 833.7, 120.1, 77.5, P<0.05). In addition, the incidence of adverse reactions was both less in the two groups, and the incidence of response of patients, operation time, the amount of lidocaine and other indicators and analgesic effect in the test group were superior to the control group(-15.4,9.2,-56.3,P<0.05). Conclusions Midazolam in CT-guided 125Ⅰ particle implantation can improve the patient's tolerance and shorten the operation time, guarantec security. |
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