| Jiao Dechao,Han Xinwei,Wang Junjie,Zhang Jianhao,Wang Yanli,Shui Shaofeng,Ren Jianzhuang,Li Zongming,Zhang Quanhui,Niu Rongfang.Preliminary experience of 125Ⅰ seed strands cavity brachytherapy for ureteral carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2017,37(7):508-513 |
| Preliminary experience of 125Ⅰ seed strands cavity brachytherapy for ureteral carcinoma |
| Received:March 14, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.07.007 |
| KeyWords:125Ⅰ seed strands Brachytherapy Ureteral carcinoma |
| FundProject:国家高新研发项目（863项目）（2015AA020301） |
| Author Name | Affiliation | E-mail | | Jiao Dechao | Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China | | | Han Xinwei | Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China | 13592583911@163.com | | Wang Junjie | Department of Radiation Oncology, Third Hospital of Peking University | | | Zhang Jianhao | Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China | | | Wang Yanli | Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China | | | Shui Shaofeng | Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China | | | Ren Jianzhuang | Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China | | | Li Zongming | Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China | | | Zhang Quanhui | Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China | | | Niu Rongfang | Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China | |
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| Abstract:: |
| Objective To evaluate the safety and efficacy of 125Ⅰ seed strands cavity brachytherapy for ureteral carcinoma. Methods To tally 10 patients with ureteral carcinoma underwent C-arm CT and DSA guided percutaneous nephrostomy with 125Ⅰ seed strands cavity brachytherapy. The technical success rate, complications, tumor local control rate, ureteral patency andsurvival time, and compared the Karnofsky scores, Girignon grade, pain score before and after treatment were evaluated.The dose related parameters were compared between pre-and post-treatment. Results 125Ⅰ seed strands implantation was successfully completed in all patients with technical success rate of 100%. The mean procedure time was (12.3±3.8) min. No severe complications such as ureteral perforation, infection, severe bleeding occurred. Local tumor response was CR in 4 cases and PR in 6 cases, showing local control efficiency (CR+PR) 100% after 2-3 months. Ureteral patency rate was 50% (5/10). Postprocedure Karnofsky scores, Girignon grades, and pain scores were significantly improved (Z=-2.72, -2.88, -2.83, P<0.01). The average follow-up time was (14.6±6.5) months (5-25 months), tumor progression was observed in 3 cases, stable disease in 7 cases. Nine cases were alive and one died due to multiple organ failure. The differences of D90%, mPD, V100%, V150%, V200%, CI, EI, HI between the pre-and post-treatment were not statistically significant (P>0.05). Conclusions 125Ⅰ seed strands cavity brachytherapy for ureteral carcinoma is an effective and safe procedure without serious complications, and an effective alternative treatment for patients who are unable to undergoor refuse surgery. |
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