| Lyu Xiaoming,Shi Yan,Liu Shuming,Huang Mingwei,Zheng Lei,Zhang Jie,Zhang Jianguo.Surgery combined with 125Ⅰ seed implantation brachytherapy for treatment of malignant submandibular gland tumors[J].Chinese Journal of Radiological Medicine and Protection,2017,37(7):505-507,556 |
| Surgery combined with 125Ⅰ seed implantation brachytherapy for treatment of malignant submandibular gland tumors |
| Received:February 20, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.07.006 |
| KeyWords:125Ⅰ Seed implantation Submandibular gland Malignant tumors |
| FundProject: |
| Author Name | Affiliation | E-mail | | Lyu Xiaoming | Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China | | | Shi Yan | Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China | | | Liu Shuming | Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China | | | Huang Mingwei | Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China | | | Zheng Lei | Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China | | | Zhang Jie | Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China | | | Zhang Jianguo | Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China | rszhang@126.com |
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| Abstract:: |
| Objective To evaluate the treatment of malignant submandibular gland tumors with surgery combined with 125Ⅰ radioactive implantation. Methods Thirty-two patients with malignant submandibular gland tumors were treated with surgery combined with 125Ⅰ seed implantation from December 2005 to December 2012. All of the 32 patients with primary disease were treated by excision of the submandibular gland and neoplasm. None of the patients received wide excision or neck dissection without the evidence of the neck metastases. The planning targets was based on computerized tomography (CT) images, tumors site, extent and pathologic type.The matched peripheral dose (mPD) was 90-110 Gy. Recurrence-free survival (RFS), overall survival (OS) rates and side effects were retrospectively reviewed. Results Totally 32 patients received 1394 radioactive seeds implantation, radioactive seeds and dose distributed were well in all patients. All patients were followed for 15-126 months (mean of 64 months), with 5 recurrence, 5 distant metastases, and 4 patients who died of disease. The 3-and 5-year RFS were 93.1% and 87.9%, and OS rates were 93.3% and 84.5%, respectively. No severe complications were observed during follow-up. Conclusions The excision of the neoplasm and the submandibular gland, combined with 125Ⅰ seed implantation brachytherapy was an effective modality for the treatment of malignant submandibular gland tumors. |
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