| Hu Chaoyue,Li Jianbin,Wang Jinzhi,Wang Wei,Li Fengxiang,Guo Yanluan.A comparison of gross tumor volume among three-dimensional, four-dimensional and cone beam computed tomography in primary esophageal cancer[J].Chinese Journal of Radiological Medicine and Protection,2017,37(6):430-436 |
| A comparison of gross tumor volume among three-dimensional, four-dimensional and cone beam computed tomography in primary esophageal cancer |
| Received:December 12, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.06.006 |
| KeyWords:Esophageal cancer Three-dimensional computed tomography Four-dimensional computed tomography Cone beam computed tomography Gross tumor volume |
| FundProject:国家重点研发计划项目（2016YFC0904700）；山东省重点研发计划项目（2016GSF201093） |
| Author Name | Affiliation | E-mail | | Hu Chaoyue | Medicine and Life Sciences College of Shandong Academy of Medical Sciences, Jinan University, Jinan 250117, China | | | Li Jianbin | Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China | lijianbin@msn.com | | Wang Jinzhi | Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China | | | Wang Wei | Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China | | | Li Fengxiang | Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China | | | Guo Yanluan | Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China | |
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| Abstract:: |
| Objective To analyze the volume and position of the gross tumor volumes (GTV) in primary esophageal cancer based on contrast-enhanced three-dimensional (3D),four-dimensional (4D) and cone beam (CB) computed tomography (CT). Methods A total of thirty-four patients underwent 3D-CT and 4D-CT simulation scans for computer treatment plan and contrast-enhanced CBCT scans were conducted prior to the first treatment.GTV3D,GTV4D50,internal GTVMIP(IGTVMIP) and internal GTVCBCT(IGTVCBCT) were delineated on 3D-CT,4D-CT50(the end expiratory phase),4D-CTMIP(the maximum intensity projection),and CBCT datasets,respectively.The IGTV10 was defined as 10 respiratory phases GTVs in 4D-CT.To evaluate the difference in position,volume and the volumes encompassed characteristic. Results The significant difference was observed in the volumes[IGTV10>(IGTVCBCT or IGTVMIP)>(GTV3D or GTV4D50)]regardless of the tumor location.Regarding IGTV10 as the standard volume,the underestimations or overestimations between IGTV10 and IGTVCBCT were larger than that of between IGTV10 and JGTVMIP(t=-8.294——3.192,P<0.05).However,there was no significant difference between the areas of IGTV10 which excluded in IGTVCBCT and IGTV3D(P>0.05).The GTV4D50/IGTVCBCT ratio for upper esophageal tumors was negatively correlated to motion vector (r=-0.756,P<0.05).The centroid coordinates of IGTVCBCT in AP direction were significantly different from the test volumes (GTV3D,GTV4D50,IGTVMIP and IGTV10)(t=-3.559——2.435,P<0.05).The IGTV10/IGTVCBCT ratio was positively correlated to motion vector (r=0.695,P<0.05) for middle esophageal tumors.The centroid coordinates of IGTVCBCT were significantly different IGTV10(t=2.201,P<0.05) in AP direction.For distal esophageal tumors,the significant difference was observed in the centroid coordinate between IGTVCBCT and IGTVMIP(t=-2.365,P<0.05) in LR direction.The percentage of IGTV10 excluded the IGTVCBCT were significantly correlated to the motion vector (r=0.540,0.678,P<0.05) for both middle and distal esophageal tumors.The mean MI value of IGTVCBCT to the other four test volumes ranged from 0.65 to 0.72. Conclusions CBCT has much motion information than 3D-CT but less than IGTV10.CBCT was similar to MIP images based on respiration motion.However,the target motion information encompassed in CBCT and MIP images cannot be exchanged to each other. |
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