| Zhang Siyuan,Tie Jian,Yu Huiming,Zhang Yibao.Comparison of survival effects between using electron and modulated X-ray beams for boosting irradiation in breast cancer patients after breast-conserving surgery and postoperative radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2017,37(5):345-351 |
| Comparison of survival effects between using electron and modulated X-ray beams for boosting irradiation in breast cancer patients after breast-conserving surgery and postoperative radiotherapy |
| Received:February 14, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.05.005 |
| KeyWords:Breast cancer Breast-conserving surgery Postoperative irradiation Tumor bed boost |
| FundProject:国家自然科学基金（11505012，81472814）；北京市自然科学基金（7172048，1174016）；北京市医院管理局“青苗”计划专项经费（QML20151004）；质检公益性行业科研专项（201510001-02） |
| Author Name | Affiliation | | Zhang Siyuan | Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | Tie Jian | Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | Yu Huiming | Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | Zhang Yibao | Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China |
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| Abstract:: |
| Objective To compare the survival effects between using electron beams (EB) and modulated X-ray beams (XB) for boosting irradiation in breast cancer patients after breast-conserving surgery and postoperative radiotherapy.Methods This study retrospectively included 485 breast cancer patients who underwent breast-conserving surgery at Beijing Cancer Hospital. All patients underwent either EB or XB for tumor bed boost irradiation (10-16 Gy/5-8 fractions) after whole-breast irradiation of 46-50 Gy/23-25 fractions. Results Median follow-up time for the cohort was 96.04 months. Statistically significant increase of local recurrence free Survival (LRFS) was observed in XB group than in EB group. The 5-year and 10-year LRFS was both 98.4% in XB group, as well as 94.2% and 93.2% in EB group, respectively (χ2=4.190,P<0.05). But there was not statistically significant difference in 5-year and 10-year overall survival (OS) between XB group(96.7% and 95.8%)and EB group(94.9% and 89.4%), respectively (P>0.05). The multivariate analysis showed that LRFS was significantly correlated with age≤40, positive pathological lymph nodes and positive expression of Her-2 receptor. But boost irradiation method was not independent prognostic factor for LRFS and OS (P>0.05). Conclusions For cancer patients treated with breast-conserving surgery and whole-breast postoperative radiation followed by a boost irradiation to tumor bed, XB irradiation was superior to EB irradiation in term of LRFS, yet no difference of OS was observed in both groups. |
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