| Ma Ningyi,Mao Jingfang,Chen Jian,et al.Preliminary clinical results after pencil beam scanning particle radiotherapy for stageⅠnon-small cell lung cancer[J].Chinese Journal of Radiological Medicine and Protection,2017,37(5):321-326 |
| Preliminary clinical results after pencil beam scanning particle radiotherapy for stageⅠnon-small cell lung cancer |
| Received:February 23, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.05.001 |
| KeyWords:Non-small cell lung cancer Radiotherapy Protons Carbon-ion Pencil beam scanning |
| FundProject:上海市科学技术委员会科研项目（15411950103） |
| Author Name | Affiliation | E-mail | | Ma Ningyi | Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai 201315, China | | | Mao Jingfang | Department of Radiation Oncology, Fudan University Cancer Hospital, Shanghai 200032, China | jingfang.mao@sphic.org.cn | | Chen Jian | Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai 201315, China | | | Jiang Guoliang | Department of Radiation Oncology, Fudan University Cancer Hospital, Shanghai 200032, China | | | Cai Xin | Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai 201315, China | | | Lu Jiade | Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai 201315, China | |
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| Abstract:: |
| Objective To evaluate the safety and efficacy of proton and carbon-ion radiotherapy (RT) for stageⅠnon-small cell lung cancer (NSCLC) with pencil beam scanning technique.Methods From August 2014 to December 2015, 10 patients with stageⅠNSCLC who were inoperable or refused surgery were treated by proton +/- carbon-ion RT. Primary lesions were irradiated using 2-4 portals with 45-degree beams. A total dose of 50-70 GyE/10 fractions, 60-64 GyE/15-16 fractions, and 66-72 GyE/22-24 fractions were administered to patients based on tumor location (4 peripheral, 3 middle, and 3 central lesions, respectively). Results At the last follow-up in December 2016 with the median follow-up of 18.1 (11.9-28.1) months, local control was found in all patients per CT or PET/CT scanning(6 complete response, 3 partial response, and 1 stable disease). However, 2 patients with local control (1 partial response and 1 stable disease) experienced a distant failure at 8.7 and 24.9 months after RT, respectively. There was no RT-related Grade 3-5 toxicity in all patients. Grade 2 toxicities were only found in 2 patients (acute skin reaction and leucopenia, respectively). At 1, 3-5 months after RT, the pulmonary function tests showed a slightly increase in FVC, FEV1 and DLCO-sb compared with those before RT without statistical significance (P>0.05). Conclusions The particle RT using pencil beam scanning technique was safe, and yielded encouraging outcome for patients with stage I NSCLC who were inoperable or refused surgery. Further follow-up and prospective clinical studies are warranted in the future. |
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